HDLBP - high density lipoprotein binding protein Gene

Also Known as HBP; VGL; PRO2900

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3069

About HDLBP

Cytogenetic location: 2q37.3 Genomic coordinates (GRCh38): 2:241,227,291-241,315,672 (from NCBI)

This gene has 47 transcripts (splice variants), 212 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 89.6), thyroid (RPKM 63.1) and 25 other tissues.

Summary

The protein encoded by this gene binds high density lipoprotein (HDL) and may function to regulate excess Cholesterol levels in cells. The encoded protein also binds RNA and can induce heterochromatin formation. [provided by RefSeq, Mar 2016]

HDLBP Products (6)

mRNA Protein Name
NM_001243900.3 NP_001230829.1 vigilin isoform b
NM_001320965.3 NP_001307894.1 vigilin isoform a
NM_001320966.3 NP_001307895.1 vigilin isoform a
NM_001320967.3 NP_001307896.1 vigilin isoform c
NM_005336.6 NP_005327.1 vigilin isoform a
NM_203346.6 NP_976221.1 vigilin isoform a

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
24725430 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HDLBP Protein Structure

KH_1

KH_1: KH domain (153 - 210)

KH_1

KH_1: KH domain (225 - 284)

KH_1

KH_1: KH domain (298 - 355)

KH_1

KH_1: KH domain (369 - 424)

KH_1

KH_1: KH domain (439 - 496)

KH_1

KH_1: KH domain (512 - 568)

KH_1

KH_1: KH domain (584 - 643)

KH_1

KH_1: KH domain (656 - 716)

KH_1

KH_1: KH domain (731 - 789)

KH_1

KH_1: KH domain (804 - 863)

KH_1

KH_1: KH domain (879 - 966)

KH_1

KH_1: KH domain (974 - 1033)

KH_1

KH_1: KH domain (1055 - 1117)

KH_1

KH_1: KH domain (1133 - 1190)

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  • 1000
  • 1200
  • 1268 a.a.
Protein Preferred Names Protein Names

vigilin

  • HDL-binding protein

HDLBP Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
HDLBP Q00341 RAD51 Homo sapiens Q06609
Anti Bait CoIP
33941620
Intra
HDLBP Q00341 CTCF Homo sapiens P49711
Anti Bait CoIP
24725430
Cross: Cross-species interaction Intra: Intraspecies interaction

HDLBP Antibodies

Cat. No. Product Name Application Reactivity
HY-P83224 HDLBP Antibody (YA2969) WB Human
HY-P83224A HDLBP Antibody (YA2969)(PBS only) WB Human

Related Diseases

Diseases Alias
Chromosome 2q37 Deletion Syndrome

  • Albright Hereditary Osteodystrophy-Like Syndrome

  • 2q37 Microdeletion Syndrome

  • Brachydactyly-Intellectual Disability Syndrome

  • Deletion 2q37

  • 2q37 Deletion Syndrome

  • Brachydactyly-Mental Retardation Syndrome

  • Bdmr

  • Albright Hereditary Osteodystrophy Type 3

  • Del(2)(Q37)

  • Monosomy 2q37qter

  • Albright'S Hereditary Osteodystrophy-Like Syndrome

  • Monosomy 2q37

  • Chromosome Deletion Syndrome 2q37
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06099 HDLBP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20952 Hdlbp Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27469 Hdlbp Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta HDLBP VGNC VGNC:73361
Rattus norvegicus HDLBP RGD RGD:620962
Bos taurus HDLBP VGNC VGNC:55051
Mus musculus HDLBP MGD MGI:99256
Felis catus HDLBP VGNC VGNC:67551
Canis familiaris HDLBP VGNC VGNC:41631
Others HDLBP NCBI