Disc1 - DISC1 scaffold protein Gene

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 307940

Summary

Enables Kinesin binding activity. Involved in several processes, including positive regulation of cell projection organization; protein localization to centrosome; and pyramidal neuron migration to cerebral cortex. Acts upstream of or within regulation of glutamatergic synaptic transmission. Located in several cellular components, including central region of growth cone; microtubule cytoskeleton; and perinuclear region of cytoplasm. Part of dynein complex and Kinesin complex. Human ortholog(s) of this gene implicated in autism spectrum disorder (multiple); bipolar disorder; chronic fatigue syndrome; major depressive disorder; and psychotic disorder (multiple). Orthologous to human DISC1 (DISC1 scaffold protein). [provided by Alliance of Genome Resources, Apr 2022]

Disc1 Products (1)

mRNA	Protein	Name
NM_175596.3	NP_783186.2	disrupted in schizophrenia 1 homolog

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables kinesin binding	IDA IDA: Inferred from direct assay	17202468	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	17035248	RGD
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	16299498	RGD
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	17202468	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in cilium assembly	IMP IMP: Inferred from mutant phenotype	20531939	RGD
involved in nervous system development	IMP IMP: Inferred from mutant phenotype	12506198	RGD
involved in positive regulation of axon extension	IMP IMP: Inferred from mutant phenotype	17202468	RGD
involved in positive regulation of cell-matrix adhesion	IMP IMP: Inferred from mutant phenotype	20479754	RGD
involved in positive regulation of neuron projection development	IMP IMP: Inferred from mutant phenotype	16299498	RGD
involved in protein localization to centrosome	IGI IGI: Inferred from genetic interaction	18762586	RGD
involved in protein localization to centrosome	IMP IMP: Inferred from mutant phenotype	18762586	RGD
involved in pyramidal neuron migration to cerebral cortex	IMP IMP: Inferred from mutant phenotype	16299498	RGD
involved in regulation of dendritic spine development	IMP IMP: Inferred from mutant phenotype	20139976	RGD
involved in regulation of neuron projection development	IMP IMP: Inferred from mutant phenotype	17035248	RGD
acts upstream of or within regulation of synaptic transmission, glutamatergic	IMP IMP: Inferred from mutant phenotype	24706880	RGD
involved in response to electrical stimulus	IEP IEP: Inferred from expression pattern	19499587	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in axon	IDA IDA: Inferred from direct assay	17202468	RGD
located in cell body	IDA IDA: Inferred from direct assay	17202468	RGD
located in central region of growth cone	IDA IDA: Inferred from direct assay	17202468	RGD
located in centrosome	IDA IDA: Inferred from direct assay	16299498	RGD
part of dynein complex	IDA IDA: Inferred from direct assay	16299498	RGD
part of kinesin complex	IDA IDA: Inferred from direct assay	17202468	RGD
located in microtubule	IDA IDA: Inferred from direct assay	17202468	RGD
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	17418909	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
disrupted in schizophrenia 1 homolog

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-108909	Chymopapain		/	Unkown
HY-121003	Aspyrone		/	Unkown
HY-RS03781	DISC1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21555	Disc1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28073	Disc1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Disc1	NCBI	NCBI:27185