ANXA6 - annexin A6 Gene

Also Known as p68; p70; ANX6; CBP68; CPB-II

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 309

About ANXA6

Cytogenetic location: 5q33.1 Genomic coordinates (GRCh38): 5:151,100,706-151,157,779 (from NCBI)

This gene has 16 transcripts (splice variants), 205 orthologues and 12 paralogues. Ubiquitous expression in fat (RPKM 141.9), appendix (RPKM 77.0) and 24 other tissues.

Summary

Annexin VI belongs to a family of calcium-dependent membrane and phospholipid binding proteins. Several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. The annexin VI gene is approximately 60 kbp long and contains 26 exons. It encodes a protein of about 68 kDa that consists of eight 68-amino acid repeats separated by linking sequences of variable lengths. It is highly similar to human annexins I and II sequences, each of which contain four such repeats. Annexin VI has been implicated in mediating the endosome aggregation and vesicle fusion in secreting epithelia during exocytosis. Alternatively spliced transcript variants have been described. [provided by RefSeq, Aug 2010]

ANXA6 Products (3)

mRNA Protein Name
NM_001155.5 NP_001146.2 annexin A6 isoform 1
NM_001193544.2 NP_001180473.1 annexin A6 isoform 2
NM_001363114.2 NP_001350043.1 annexin A6 isoform 3

ANXA6 Protein Structure

Annexin

Annexin: Annexin (24 - 89)

Annexin

Annexin: Annexin (97 - 161)

Annexin

Annexin: Annexin (179 - 244)

Annexin

Annexin: Annexin (255 - 320)

Annexin

Annexin: Annexin (368 - 432)

Annexin

Annexin: Annexin (439 - 504)

Annexin

Annexin: Annexin (527 - 593)

Annexin

Annexin: Annexin (604 - 668)

  • 0
  • 200
  • 400
  • 600
  • 673 a.a.
Protein Preferred Names Protein Names

annexin A6

  • 67 kDa calelectrin

ANXA6 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ANXA6 P08133 IL16 Homo sapiens Q14005-2
Y2H Prey Pooling
32296183
Intra
ANXA6 P08133 IL16 Homo sapiens Q14005-2
Validated Y2H
32296183
Intra
ANXA6 P08133 IL16 Homo sapiens Q14005-2
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ANXA6 Proteins

Cat. No. Product Name Accession Purity
HY-P7518 Annexin A6/ANXA6 Protein, Human (His) P08133 (A2-D673) ≥ 95%, as determined by reducing SDS-PAGE.

ANXA6 Antibodies

Cat. No. Product Name Application Reactivity
HY-P80945 Annexin VI Antibody (YA618) WB, IHC-P, IP Human, Mouse, Rat
HY-P80945A Annexin VI Antibody (YA618)(PBS only) WB, IHC-P, IP Human, Mouse, Rat
HY-P85575 Annexin VI Antibody (YA5267) WB Human

Related Diseases

Diseases Alias
Kwashiorkor

  • Kwashiokor

  • Nutritional Edema With Dyspigmentation Of Skin And Hair

  • Nutritional Oedema With Dyspigmentation Of Skin And/Or Hair
Malignant Hyperthermia

  • Anesthesia Related Hyperthermia

  • Malignant Hyperpyrexia Due To Anesthesia

  • Hyperpyrexia, Malignant

  • Hyperthermia, Malignant

  • Malignant Hyperpyrexia

  • Mhs

  • Malignant Fever
Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2b

  • Lgmd2b

  • Lgmd3

  • Limb-Girdle Muscular Dystrophy Due To Dysferlin Deficiency

  • Limb-Girdle Muscular Dystrophy Type 3

  • Muscular Dystrophy, Limb-Girdle, Type 2b
Cystic Fibrosis

  • Mucoviscidosis

  • CF

  • Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis

  • Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis

  • Cystic Fibrosis Lung Disease, Modifier Of

  • Cystic Fibrosis Of Pancreas

  • Fibrocystic Disease Of Pancreas

  • Cf - [Cystic Fibrosis]

  • Cystic Fibrosis Nos

  • Fibrocystic Disease

  • Fibrocystic Disease Of The Pancreas

  • Mucoviscidosis Of Pancreas

  • Nonproliferative Fibrocystic Disease

  • Pancreatic Cystic Fibrosis
Autosomal Recessive Limb-Girdle Muscular Dystrophy

  • Muscular Dystrophy, Limb-Girdle, Autosomal Recessive
Amyotrophic Lateral Sclerosis 1

  • Amyotrophic Lateral Sclerosis

  • ALS

  • Lou Gehrig Disease

  • Amyotrophic Lateral Sclerosis Type 1

  • Charcot Disease

  • ALS1

  • Amyotrophic Lateral Sclerosis, Susceptibility To

  • Fals

  • Lou Gehrig'S Disease

  • Mnd

  • Motor Neuron Disease

  • Familial Amyotrophic Lateral Sclerosis

  • Amyotrophic Lateral Sclerosis 1, Familial

  • Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

  • Motor Neuron Disease, Bulbar

  • Motor Neurone Disease

  • Amyotrophic Lateral Sclerosis With Dementia

  • Dementia With Amyotrophic Lateral Sclerosis

  • Motor Neuron Disease, Amyotrophic Lateral Sclerosis

  • Sclerosis, Lateral, Amyotrophic

  • Sclerosis, Lateral, Amyotrophic, Type 1

  • Amyotrophic Sclerosis

  • Als - [Amyotrophic Lateral Sclerosis]

  • Wasting Palsy

  • Amyotrophic Paralysis

  • Amyotrophy Lateral Sclerosis

  • Wasting Paralysis

  • Spinal Progressive Amyotrophy

  • Progressive Atrophic Paralysis
Alzheimer Disease, Familial, 1

  • Alzheimer Disease

  • Alzheimer'S Disease

  • Presenile And Senile Dementia

  • AD1

  • Alzheimer Disease, Susceptibility To

  • Alzheimer Disease, Late-Onset, Susceptibility To

  • Alzheimer Disease 1, Familial

  • AD

  • Familial Alzheimer Disease

  • Alzheimer Disease, Late-Onset

  • Alzheimers Dementia

  • Alzheimer Dementia

  • Alzheimer Sclerosis

  • Alzheimer Syndrome

  • Alzheimer-Type Dementia

  • Dat

  • Primary Senile Degenerative Dementia

  • Sdat

  • Alzheimer Disease 1

  • Autosomal Dominant Alzheimer Disease

  • Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy

  • Late Onset Alzheimer Disease

  • Alzheimers Disease

  • Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy

  • Late-Onset Alzheimers Disease

  • Alzheimer'S Disease Pathway Kegg

  • Dementia Due To Alzheimer'S Disease

  • Alzheimer Disease Type 1

  • Alzheimers
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS24635 Anxa6 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus ANXA6 RGD RGD:621172
Bos taurus ANXA6 VGNC VGNC:25968
Felis catus ANXA6 VGNC VGNC:67705
Macaca mulatta ANXA6 VGNC VGNC:69951
Mus musculus ANXA6 MGD MGI:88255
Canis familiaris ANXA6 VGNC VGNC:37943
Others ANXA6 NCBI