Ms4a1 - membrane spanning 4-domains A1 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 309217

About Ms4a1

Primary_assembly 1: 207,906,374-207,918,512 reverse strand.mRatBN7.2:CM026974.1

This gene has 1 transcript (splice variant), 280 orthologues, 22 paralogues and is associated with 11 phenotypes. Biased expression in Spleen (RPKM 916.9) and Thymus (RPKM 119.5).

Summary

Enables epidermal growth factor receptor binding activity. Predicted to be involved in several processes, including B cell receptor signaling pathway; calcium ion transport; and protein tetramerization. Predicted to act upstream of or within response to bacterium. Predicted to be located in external side of plasma membrane; nucleoplasm; and plasma membrane raft. Biomarker of glomerulonephritis. Human ortholog(s) of this gene implicated in common variable immunodeficiency. Orthologous to human MS4A1 (membrane spanning 4-domains A1). [provided by Alliance of Genome Resources, Apr 2022]

Ms4a1 Products (1)

mRNA Protein Name
NM_001399452.1 NP_001386381.1 B-lymphocyte antigen CD20

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables epidermal growth factor receptor binding IPI
IPI: Inferred from physical interaction
21349584 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ms4a1 Protein Structure

CD20

CD20: pfam04103 (50 - 216)

  • 0
  • 100
  • 200
  • 298 a.a.
Protein Preferred Names Protein Names

B-lymphocyte antigen CD20

  • membrane-spanning 4-domains, subfamily A, member 1

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (3)
Cat. No. Product Name Effect
Purity Phase
HY-P990649 PF-5212374 Inhibitor 97.9% Phase 2
HY-P99308 Ocaratuzumab Inhibitor 95.00% Phase 1
HY-P991671 Anafiltamig Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08696 MS4A1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08697 Ms4a1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08698 Ms4a1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18183 Ms4a2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24657 Ms4a2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990054 Eramkafusp Alfa / Unkown
HY-P992104 Blidarvetug Inhibitor / Unkown
HY-P992144 Zareprumig Inhibitor 95.34% Unkown
HY-P991546 MEDI-552 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ms4a1 NCBI NCBI:931