Ms4a1 - membrane spanning 4-domains A1 Gene

Rattus norvegicus

Gene ID: 309217 | Gene type: protein coding

About Ms4a1

Primary_assembly 1: 207,906,374-207,918,512 reverse strand.mRatBN7.2:CM026974.1

This gene has 1 transcript (splice variant), 280 orthologues, 22 paralogues and is associated with 11 phenotypes. Biased expression in Spleen (RPKM 916.9) and Thymus (RPKM 119.5).

Summary

Enables epidermal growth factor receptor binding activity. Predicted to be involved in several processes, including B cell receptor signaling pathway; calcium ion transport; and protein tetramerization. Predicted to act upstream of or within response to bacterium. Predicted to be located in external side of plasma membrane; nucleoplasm; and plasma membrane raft. Biomarker of glomerulonephritis. Human ortholog(s) of this gene implicated in common variable immunodeficiency. Orthologous to human MS4A1 (membrane spanning 4-domains A1). [provided by Alliance of Genome Resources, Apr 2022]

Ms4a1 Products(1)

mRNA	Protein	Name
NM_001399452.1	NP_001386381.1	B-lymphocyte antigen CD20

Ms4a1 Protein Structure

CD20

0
100
200
298 a.a.

Protein Preferred Names

Protein Names

B-lymphocyte antigen CD20

membrane-spanning 4-domains, subfamily A, member 1

Related Agents

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99308	Ocaratuzumab	Inhibitor	95.00%	Phase 1

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Purity	Rare Diseases
HY-RS08696	MS4A1 Human Pre-designed siRNA Set A	/	Unkown
HY-RS08697	Ms4a1 Mouse Pre-designed siRNA Set A	/	Unkown
HY-RS08698	Ms4a1 Rat Pre-designed siRNA Set A	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990054	Eramkafusp Alfa		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ms4a1	NCBI	NCBI:931
Macaca fascicularis	Ms4a1	NCBI	NCBI:102118491
Canis lupus familiaris	Ms4a1	NCBI
Mus musculus	Ms4a1	NCBI	NCBI:12482

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