HK3 - hexokinase 3 Gene

Also Known as HXK3; HKIII

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3101

About HK3

Cytogenetic location: 5q35.2 Genomic coordinates (GRCh38): 5:176,880,869-176,899,346 (from NCBI)

This gene has 6 transcripts (splice variants), 129 orthologues and 4 paralogues. Biased expression in bone marrow (RPKM 50.3), spleen (RPKM 14.0) and 3 other tissues.

Summary

Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes Hexokinase 3. Similar to hexokinases 1 and 2, this allosteric enzyme is inhibited by its product glucose-6-phosphate. [provided by RefSeq, Apr 2009]

HK3 Products (1)

mRNA Protein Name
NM_002115.3 NP_002106.2 hexokinase-3

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables hexokinase activity IDA
IDA: Inferred from direct assay
8717435 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HK3 Protein Structure

Hexokinase_1

Hexokinase_1: Hexokinase (28 - 231)

Hexokinase_2

Hexokinase_2: Hexokinase (237 - 475)

Hexokinase_1

Hexokinase_1: Hexokinase (480 - 675)

Hexokinase_2

Hexokinase_2: Hexokinase (677 - 916)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 923 a.a.
Protein Preferred Names Protein Names

hexokinase-3

  • ATP:D-hexose 6-phosphotransferase

HK3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
HK3 P52790 DNM2 Homo sapiens P50570-2
Y2H Pooling
32814053
Intra
HK3 P52790 DNM2 Homo sapiens P50570-2
Validated Y2H
32814053
Intra
HK3 P52790 DNM2 Homo sapiens P50570-2
Y2H Array
32814053
Intra
HK3 P52790 ATN1 Homo sapiens Q86V38
Validated Y2H
32814053
Intra
HK3 P52790 ATN1 Homo sapiens Q86V38
Y2H Pooling
32814053
Intra
HK3 P52790 ATN1 Homo sapiens Q86V38
Y2H Array
32814053
Intra
HK3 P52790 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra
HK3 P52790 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra
HK3 P52790 MEOX2 Homo sapiens Q6FHY5
Validated Y2H
32296183
Intra
HK3 P52790 APBB2 Homo sapiens Q92870-2
Y2H Pooling
32814053
Intra
HK3 P52790 APBB2 Homo sapiens Q92870-2
Validated Y2H
32814053
Intra
HK3 P52790 APBB2 Homo sapiens Q92870-2
Y2H Array
32814053
Intra
HK3 P52790 CCT5 Homo sapiens P48643
Validated Y2H
32814053
Intra
HK3 P52790 CCT5 Homo sapiens P48643
Y2H Array
32814053
Intra
HK3 P52790 CCT5 Homo sapiens P48643
Y2H Pooling
32814053
Intra
HK3 P52790 WFS1 Homo sapiens O76024
Validated Y2H
32814053
Intra
HK3 P52790 WFS1 Homo sapiens O76024
Y2H Pooling
32814053
Intra
HK3 P52790 WFS1 Homo sapiens O76024
Y2H Array
32814053
Intra
HK3 P52790 PRPS1 Homo sapiens P60891
Validated Y2H
32814053
Intra
HK3 P52790 PRPS1 Homo sapiens P60891
Y2H Pooling
32814053
Intra
HK3 P52790 PRPS1 Homo sapiens P60891
Y2H Array
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant HK3 Proteins

Cat. No. Product Name Accession Purity
HY-P74881 HK3/Hexokinase-3 Protein, Human (sf9, His-GST) P52790 (M1-V923) ≥ 85%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07381 KLK3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-170799 HNC-1664 Inhibitor / Unkown
HY-183809 ZSW Inhibitor / Unkown
HY-RS06194 HK3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06289 HOOK3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19297 Hk3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25788 Hk3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris HK3 VGNC VGNC:41700
Felis catus HK3 VGNC VGNC:67581
Rattus norvegicus HK3 RGD RGD:2798
Bos taurus HK3 VGNC VGNC:29866
Macaca mulatta HK3 VGNC VGNC:73476
Mus musculus HK3 MGD MGI:2670962
Others HK3 NCBI