Itga4 - integrin subunit alpha 4 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 311144

Summary

Enables cell adhesion molecule binding activity; fibronectin binding activity; and protein antigen binding activity. Involved in several processes, including clathrin-dependent extracellular exosome endocytosis; neuron projection morphogenesis; and regulation of leukocyte migration. Located in several cellular components, including extracellular exosome; growth cone; and neuronal cell body. Used to study anti-basement membrane glomerulonephritis; diabetic retinopathy; nephritis; and pneumonia. Biomarker of pre-eclampsia. Human ortholog(s) of this gene implicated in autism spectrum disorder and pancreatic Cancer. Orthologous to human ITGA4 (Integrin subunit alpha 4). [provided by Alliance of Genome Resources, Apr 2022]

Itga4 Products (1)

mRNA Protein Name
NM_001107737.1 NP_001101207.1 integrin alpha-4

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables antigen binding IPI
IPI: Inferred from physical interaction
20124479 RGD
enables cell adhesion molecule binding IMP
IMP: Inferred from mutant phenotype
9773789 RGD
enables fibronectin binding IMP
IMP: Inferred from mutant phenotype
9773789 RGD
enables protein antigen binding IPI
IPI: Inferred from physical interaction
20124479 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
20124479 RGD
Biological Process GO Annotation Evidence References Source
involved in axonogenesis involved in innervation IMP
IMP: Inferred from mutant phenotype
16181811 RGD
involved in cellular response to cytokine stimulus IEP
IEP: Inferred from expression pattern
12046991 RGD
involved in clathrin-dependent extracellular exosome endocytosis IMP
IMP: Inferred from mutant phenotype
20124479 RGD
involved in diapedesis IMP
IMP: Inferred from mutant phenotype
8550078 RGD
involved in import into cell IMP
IMP: Inferred from mutant phenotype
20124479 RGD
involved in neuron projection extension IMP
IMP: Inferred from mutant phenotype
16181811 RGD
involved in positive regulation of T cell migration IMP
IMP: Inferred from mutant phenotype
8580084 RGD
involved in positive regulation of leukocyte cell-cell adhesion IMP
IMP: Inferred from mutant phenotype
7680140 RGD
involved in positive regulation of leukocyte migration IMP
IMP: Inferred from mutant phenotype
8550078 RGD
involved in positive regulation of leukocyte tethering or rolling IMP
IMP: Inferred from mutant phenotype
9394821 RGD
Cellular Component GO Annotation Evidence References Source
located in cell surface IDA
IDA: Inferred from direct assay
9773789 RGD
located in growth cone IDA
IDA: Inferred from direct assay
12486170 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
12486170 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

integrin alpha-4

  • integrin, alpha 4

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99184 Abrilumab 98.35% Phase 2

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06951 ITGA4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17832 Itga4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24300 Itga4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Itga4 NCBI NCBI:3676