EPHB2 - Ephb2 Eph receptor B2 Gene

Also Known as RGD1564232

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 313633

Summary

Predicted to enable several functions, including amyloid-beta binding activity; identical protein binding activity; and transmembrane signaling receptor activity. Involved in several processes, including cell junction assembly; positive regulation of nervous system development; and regulation of gene expression. Located in Golgi apparatus; cell surface; and dendritic spine. Is active in glutamatergic synapse. Used to study irritable bowel syndrome and ulcerative colitis. Biomarker of irritable bowel syndrome and middle cerebral artery infarction. Human ortholog(s) of this gene implicated in blood platelet disease. Orthologous to human EphB2 (EPH receptor B2). [provided by Alliance of Genome Resources, Apr 2022]

EPHB2 Products (1)

mRNA Protein Name
NM_001127319.3 NP_001120791.2 ephrin type-B receptor 2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
21113149 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to amyloid-beta IEP
IEP: Inferred from expression pattern
23831214 RGD
involved in cellular response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
33794069 RGD
involved in hindbrain tangential cell migration IMP
IMP: Inferred from mutant phenotype
28276447 RGD
involved in negative regulation of cytokine production involved in inflammatory response IDA
IDA: Inferred from direct assay
33722292 RGD
involved in positive regulation of dendritic spine morphogenesis IMP
IMP: Inferred from mutant phenotype
21364901 RGD
involved in positive regulation of gene expression IMP
IMP: Inferred from mutant phenotype
21113149 RGD
involved in positive regulation of protein localization to cell surface IDA
IDA: Inferred from direct assay
19160501 RGD
involved in positive regulation of protein localization to plasma membrane IMP
IMP: Inferred from mutant phenotype
21113149 RGD
involved in positive regulation of synapse assembly IMP
IMP: Inferred from mutant phenotype
21364901 RGD
involved in postsynaptic membrane assembly IDA
IDA: Inferred from direct assay
11136979 RGD
involved in postsynaptic membrane assembly IEP
IEP: Inferred from expression pattern
11136979 RGD
involved in postsynaptic membrane assembly IMP
IMP: Inferred from mutant phenotype
11136979 RGD
involved in regulation of T-helper 17 type immune response IDA
IDA: Inferred from direct assay
33722292 RGD
involved in regulation of behavioral fear response IMP
IMP: Inferred from mutant phenotype
26354908 RGD
involved in regulation of filopodium assembly IMP
IMP: Inferred from mutant phenotype
21364901 RGD
involved in regulation of receptor signaling pathway via JAK-STAT IDA
IDA: Inferred from direct assay
33722292 RGD
involved in tight junction assembly IDA
IDA: Inferred from direct assay
33722292 RGD
involved in vesicle-mediated intercellular transport IDA
IDA: Inferred from direct assay
33722292 RGD
Cellular Component GO Annotation Evidence References Source
located in cell surface IDA
IDA: Inferred from direct assay
15965473 RGD
located in dendrite IDA
IDA: Inferred from direct assay
15965473 RGD
located in dendritic spine IDA
IDA: Inferred from direct assay
16394100 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
11136979 RGD
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
11136979 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
15965473 RGD
located in postsynapse IDA
IDA: Inferred from direct assay
19160501 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ephrin type-B receptor 2

  • ephrin type-B receptor 2-like

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (11)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-18833 ALW-II-49-7 Inhibitor 99.97% Unkown
HY-P5438 Srctide Substrate 99.71% Unkown
HY-170517 PKMYT1-IN-8 Inhibitor 99.31% Unkown
HY-179572 STA-013 99.18% Unkown
HY-146375 UniPR505 Antagonist 99.68% Unkown
HY-157019 UniPR1447 Antagonist 99.46% Unkown
HY-P10630 Pep63 Inhibitor / Unkown
HY-RS04434 EPHB2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17199 Ephb2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23651 Ephb2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24537 Ephb1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990405 Anti-EphB2 Antibody Inhibitor 99.36% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens EPHB2 NCBI NCBI:2048