Rad21 - RAD21 cohesin complex component Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 314949

Summary

Predicted to enable chromatin binding activity. Predicted to be involved in several processes, including nuclear division; regulation of cell cycle process; and replication-born double-strand break repair via sister chromatid exchange. Predicted to be located in chromosome and nuclear lumen. Predicted to be part of nuclear meiotic cohesin complex and nuclear mitotic cohesin complex. Predicted to be active in synaptonemal complex. Human ortholog(s) of this gene implicated in Cornelia de Lange syndrome 4; hepatocellular carcinoma; and lung non-small cell carcinoma. Orthologous to human RAD21 (RAD21 cohesin complex component). [provided by Alliance of Genome Resources, Apr 2022]

Rad21 Products (1)

mRNA Protein Name
NM_001025701.1 NP_001020872.1 double-strand-break repair protein rad21 homolog

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription factor binding IPI
IPI: Inferred from physical interaction
36538854 RGD
enables lncRNA binding IDA
IDA: Inferred from direct assay
33741460 RGD
Biological Process GO Annotation Evidence References Source
involved in negative regulation of gene expression IMP
IMP: Inferred from mutant phenotype
36538854 RGD
involved in negative regulation of glial cell apoptotic process IMP
IMP: Inferred from mutant phenotype
36538854 RGD
involved in negative regulation of interleukin-1 beta production IMP
IMP: Inferred from mutant phenotype
36538854 RGD
involved in negative regulation of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
33741460 RGD
involved in negative regulation of tumor necrosis factor production IMP
IMP: Inferred from mutant phenotype
36538854 RGD
involved in positive regulation of gene expression IMP
IMP: Inferred from mutant phenotype
36538854 RGD
involved in positive regulation of interleukin-10 production IMP
IMP: Inferred from mutant phenotype
36538854 RGD
involved in response to hypoxia IEP
IEP: Inferred from expression pattern
33741460 RGD
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
36538854 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

double-strand-break repair protein rad21 homolog

  • RAD21 homolog

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11599 RAD21 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-P10931F RAD21 (356–395), biotin labeled / Unkown
HY-RS20093 Rad21 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26596 Rad21 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rad21 NCBI NCBI:5885