Muc16 - mucin 16, cell surface associated Gene

Also Known as RGD1308422

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 315451

Summary

Predicted to act upstream of or within negative regulation of epithelial cell proliferation; negative regulation of interleukin-6 production; and negative regulation of wound healing. Located in extracellular space. Biomarker of ovarian carcinoma. Human ortholog(s) of this gene implicated in ovarian Cancer. Orthologous to human MUC16 (Mucin 16, cell surface associated). [provided by Alliance of Genome Resources, Apr 2022]

Muc16 Products (1)

mRNA Protein Name
XM_039082803.1 XP_038938731.1 mucin-16

Gene Ontology

  • Cellular Component
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
23983360 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

mucin-16

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Phase
HY-P99539 Ubamatamab ≥99.0% Phase 2
HY-P99593 Sofituzumab vedotin 98.97% Phase 1

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08835 MUC16 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18071 Muc16 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24546 Muc16 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P99237 Sofituzumab Inhibitor 99.90% Unkown
HY-P991166 Ubletamig Inhibitor / Unkown
HY-P992270 Anti-MUC16 Antibody (MMUC3333A) / Unkown
HY-P990830 Anti-MUC16 Antibody (VK8) Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Muc16 NCBI NCBI:94025