Ubamatamab
Based on 1 Customer Validation
Ubamatamab (REGN4018) is a humanized bispecific antibody targeted against Mucin 16 (MUC16) and CD3. Ubamatamab demonstrates potent antitumor activity.
For research use only. We do not sell to patients.
- Purity: ≥99.0%
- CAS No.: 2305629-50-7
- Molecular Weight:146.081 kDa
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
Human IgG4 kappa
Human
CD3E & MUC16
Ubamatamab (REGN4018; 0.1 pM-10 nM; 48 hours) induces human T cells and cynomolgus T cells to kill OVCAR-3 cells (EC50, 13.6 pM and 30.6 pM, respectively)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:OVCAR-3 cells
-
Concentration:0.1 pM-10 nM
-
Incubation Time:48 hours
-
Result:Induced human T cells and cynomolgus T cells to kill OVCAR-3 cells.
Ubamatamab (REGN4018; 0.01-1 mg/kg; i.p; once a week; total of five doses) shows minimal and transient increases in serum cytokines and C-reactive protein, with no overt toxicity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:NOD SCID gamma (NSG) mice injected with OVCAR-3/Luc cells[1]
-
Dosage:0.01 mg/kg, 0.1 mg/kg, 0.5 mg/kg
-
Administration:i.p; on days 6, 10, 13, 16, and 21
-
Result:Significantly reduced tumor burden, and did not result in any changes in weight.
-
Animal Model:Cynomolgus monkeys
-
Dosage:0.01, 0.1, or 1 mg/kg
-
Administration:i.p; once a week; total of five doses
-
Result:Showed minimal and transient increases in serum cytokines and C-reactive protein.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
-
Human IgG4 kappa
ELISA, FACS, Functional assay
-
Immobilized CA125 Protein, Human can bind Ubamatamab. The EC50 for this effect is 8.59 ng/mL. -
Flow cytometric analysis of 1×106 Jurkat cells labelling CD3E (red) with Ubamatamab (HY-P99539). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG4 kappa Isotype Control (HY-P99003, blue) was used as the isotype control.
Chemical Information
-
CAS No. 2305629-50-7
-
Appearance Liquid
-
Molecular Weight 146.081 kDa
-
Color Colorless to light yellow
-
SMILES
[Ubamatamab]
-
Synonyms
REGN4018
-
Shipping
Shipping with dry ice.
-
Formulation
Please refer to the lot-specific COA for specific buffer information.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
-
Data Sheet (260 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
-
Inhibitory Antibodies User Guide (603 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)