2. Gene
  3. HMGCS1 - 3-hydroxy-3-methylglutaryl-CoA synthase 1 Gene

HMGCS1 - 3-hydroxy-3-methylglutaryl-CoA synthase 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as HMGCS

Gene ID: 3157 | Gene type: protein coding

About HMGCS1

Cytogenetic location: 5p12 Genomic coordinates (GRCh38): 5:43,287,470-43,313,412 (from NCBI)

This gene has 7 transcripts (splice variants), 205 orthologues and 1 paralogue. Ubiquitous expression in brain (RPKM 48.5), liver (RPKM 37.3) and 23 other tissues.

Summary

Enables protein homodimerization activity. Predicted to be involved in acetyl-CoA metabolic process and farnesyl diphosphate biosynthetic process, mevalonate pathway. Predicted to be located in cytoplasm. Predicted to be active in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

HMGCS1 Products(9)

mRNA Protein Name
NM_001098272.3 NP_001091742.1 hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform 1
NM_001324219.2 NP_001311148.1 hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform 1
NM_001324220.2 NP_001311149.1 hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform 1
NM_001324222.2 NP_001311151.1 hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform 2
NM_001324223.2 NP_001311152.1 hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform 2
NM_001324224.2 NP_001311153.1 hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform 2
NM_001330663.2 NP_001317592.1 hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform 1
NM_001364188.2 NP_001351117.1 hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform 1
NM_002130.8 NP_002121.4 hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform 1

HMGCS1 Protein Structure

HMG_CoA_synt_N

HMG_CoA_synt_N: Hydroxymethylglutaryl-coenzyme A synthase N terminal (13 - 186)

HMG_CoA_synt_C

HMG_CoA_synt_C: Hydroxymethylglutaryl-coenzyme A synthase C terminal (187 - 469)

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  • 520 a.a.
Protein Preferred Names Protein Names

hydroxymethylglutaryl-CoA synthase, cytoplasmic

3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) synthase

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS06241 HMGCS1 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus HMGCS1 VGNC VGNC:67597
Canis familiaris HMGCS1 VGNC VGNC:103681
Bos taurus HMGCS1 VGNC VGNC:29880
Rattus norvegicus HMGCS1 RGD RGD:70970
Macaca mulatta HMGCS1 VGNC VGNC:73485
Mus musculus HMGCS1 MGD MGI:107592