Pml - PML nuclear body scaffold Gene

Predicted to enable several functions, including protein dimerization activity; transition metal ion binding activity; and ubiquitin-like protein transferase activity. Predicted to be involved in several processes, including regulation of cellular protein metabolic process; regulation of nucleobase-containing compound metabolic process; and signal transduction by p53 class mediator. Predicted to act upstream of or within several processes, including apoptotic signaling pathway; positive regulation of macromolecule metabolic process; and protein localization to nucleus. Predicted to be located in chromosome, telomeric region; cytosol; and nucleus. Predicted to be extrinsic component of endoplasmic reticulum membrane. Predicted to be active in PML body and chromatin. Predicted to colocalize with heterochromatin. Human ortholog(s) of this gene implicated in acute promyelocytic leukemia and skin Cancer. Orthologous to human PML (PML nuclear body scaffold). [provided by Alliance of Genome Resources, Apr 2022]