SLC29A2 - solute carrier family 29 member 2 Gene

Also Known as ENT2; DER12; HNP36

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3177

About SLC29A2

Cytogenetic location: 11q13.2 Genomic coordinates (GRCh38): 11:66,362,521-66,372,446 (from NCBI)

This gene has 7 transcripts (splice variants), 266 orthologues and 3 paralogues. Ubiquitous expression in duodenum (RPKM 6.4), small intestine (RPKM 4.5) and 23 other tissues.

Summary

The uptake of nucleosides by transporters, such as SLC29A2, is essential for nucleotide synthesis by salvage pathways in cells that lack de novo biosynthetic pathways. Nucleoside transport also plays a key role in the regulation of many physiologic processes through its effect on adenosine concentration at the cell surface (Griffiths et al., 1997 [PubMed 9396714]).[supplied by OMIM, Nov 2008]

SLC29A2 Products (3)

mRNA	Protein	Name
NM_001300868.2	NP_001287797.1	equilibrative nucleoside transporter 2 isoform a
NM_001300869.2	NP_001287798.1	equilibrative nucleoside transporter 2 isoform b
NM_001532.3	NP_001523.2	equilibrative nucleoside transporter 2 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables adenine transmembrane transporter activity	IDA IDA: Inferred from direct assay	21795683	GOA
enables cytidine transmembrane transporter activity	IDA IDA: Inferred from direct assay	10722669	GOA
enables guanine transmembrane transporter activity	IDA IDA: Inferred from direct assay	21795683	GOA
enables neurotransmitter transmembrane transporter activity	IDA IDA: Inferred from direct assay	9396714	GOA
enables nucleobase transmembrane transporter activity	IDA IDA: Inferred from direct assay	16214850	GOA
enables nucleoside transmembrane transporter activity	IDA IDA: Inferred from direct assay	9396714	GOA
enables purine nucleoside transmembrane transporter activity	IDA IDA: Inferred from direct assay	9396714	GOA
enables uracil transmembrane transporter activity	IDA IDA: Inferred from direct assay	21795683	GOA
enables uridine transmembrane transporter activity	IDA IDA: Inferred from direct assay	9396714	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in adenine transport	IDA IDA: Inferred from direct assay	21795683	GOA
involved in adenosine transport	IDA IDA: Inferred from direct assay	9396714	GOA
involved in cytidine transport	IDA IDA: Inferred from direct assay	10722669	GOA
involved in guanine transmembrane transport	IDA IDA: Inferred from direct assay	21795683	GOA
involved in hypoxanthine transport	IDA IDA: Inferred from direct assay	16214850	GOA
involved in inosine transport	IDA IDA: Inferred from direct assay	10722669	GOA
involved in neurotransmitter transport	IDA IDA: Inferred from direct assay	9396714	GOA
involved in nucleobase transport	IDA IDA: Inferred from direct assay	16214850	GOA
involved in nucleoside transmembrane transport	IDA IDA: Inferred from direct assay	9396714	GOA
involved in nucleoside transport	IDA IDA: Inferred from direct assay	9396714	GOA
involved in purine nucleobase transmembrane transport	IDA IDA: Inferred from direct assay	16214850	GOA
involved in purine nucleoside transmembrane transport	IDA IDA: Inferred from direct assay	9396714	GOA
involved in pyrimidine-containing compound transmembrane transport	IDA IDA: Inferred from direct assay	9396714	GOA
involved in thymine transport	IDA IDA: Inferred from direct assay	21795683	GOA
involved in uracil transmembrane transport	IDA IDA: Inferred from direct assay	21795683	GOA
involved in uridine transmembrane transport	IDA IDA: Inferred from direct assay	9396714	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	23639800	GOA
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	12527552	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC29A2 Protein Structure

Nucleoside_tran

0
100
200
300
400
456 a.a.

Protein Preferred Names	Protein Names
equilibrative nucleoside transporter 2	36 kDa nucleolar protein HNP36

SLC29A2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P810759	ENT2 Antibody (YA10002)	WB, IHC-P, ICC/IF	Human
HY-P82697	ENT2 Antibody (YA2442)	WB, ICC/IF, FC	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Hepatic Adenomas, Familial	Hepatic Adenoma, Somatic Familial Hepatic Adenoma Familial Liver Cell Adenomas Liver Cell Adenomas, Familial Hepatic Adenomas Familial HEPAF Ha Hepatocellular Adenomas Hepatocellular Adenoma
Leukemia, Chronic Lymphocytic	Chronic Lymphocytic Leukemia B-Cell Chronic Lymphocytic Leukemia CLL B-Cell Chronic Lymphoid Leukemia Chronic Lymphatic Leukemia Chronic Lymphocytic Leukaemia Lymphoplasmacytic Leukemia Small Lymphocytic Lymphoma Leukemia, Chronic Lymphatic B-Cell Chronic Lymphocytic Leukaemia Chronic Lymphatic Leukaemia Lymphoplasmacytic Leukaemia B Cell Chronic Lymphocytic Leukemia Chronic B-Cell Lymphocytic Leukemia Leukemia, Lymphocytic, Chronic B-Cll Chronic Lymphoid Leukemia Leukemia Lymphocytic Chronic Lymphoma Small Lymphocytic Leukemia, Lymphocytic, Chronic, B-Cell

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13154	SLC29A2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	SLC29A2	VGNC	VGNC:65296
Macaca mulatta	SLC29A2	VGNC	VGNC:77446
Rattus norvegicus	SLC29A2	RGD	RGD:69296
Bos taurus	SLC29A2	VGNC	VGNC:34794
Canis familiaris	SLC29A2	VGNC	VGNC:46334
Mus musculus	SLC29A2	MGD	MGI:1345278
Others	SLC29A2	NCBI