Tigar - Trp53 induced glycolysis regulatory phosphatase Gene

Also Known as 9630033F20Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 319801

Summary

Enables fructose-2,6-bisphosphate 2-phosphatase activity. Involved in negative regulation of neuron death and response to ischemia. Acts upstream of or within several processes, including fructose 2,6-bisphosphate metabolic process; negative regulation of catabolic process; and positive regulation of cardiac muscle cell apoptotic process. Located in mitochondrion. Is expressed in brain; immune system; and liver. Orthologous to human TIGAR (TP53 induced glycolysis regulatory Phosphatase). [provided by Alliance of Genome Resources, Apr 2022]

Tigar Products (1)

mRNA Protein Name
NM_177003.5 NP_795977.1 fructose-2,6-bisphosphatase TIGAR

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables fructose-2,6-bisphosphate 2-phosphatase activity IMP
IMP: Inferred from mutant phenotype
20935145 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of cardiac muscle cell apoptotic process IMP
IMP: Inferred from mutant phenotype
22044588 MGI
acts upstream of or within fructose 2,6-bisphosphate metabolic process IMP
IMP: Inferred from mutant phenotype
20935145 MGI
acts upstream of glucose catabolic process to lactate via pyruvate IMP
IMP: Inferred from mutant phenotype
20935145 MGI
acts upstream of glycolytic process IDA
IDA: Inferred from direct assay
20935145 MGI
acts upstream of or within intestinal epithelial cell development IMP
IMP: Inferred from mutant phenotype
23726973 MGI
acts upstream of mitophagy IMP
IMP: Inferred from mutant phenotype
22044588 MGI
acts upstream of or within negative regulation of glucose catabolic process to lactate via pyruvate IMP
IMP: Inferred from mutant phenotype
20935145 MGI
acts upstream of or within negative regulation of glycolytic process IDA
IDA: Inferred from direct assay
20935145 MGI
acts upstream of or within negative regulation of mitophagy IMP
IMP: Inferred from mutant phenotype
22044588 MGI
acts upstream of or within negative regulation of reactive oxygen species metabolic process IMP
IMP: Inferred from mutant phenotype
22044588 MGI
acts upstream of or within positive regulation of cardiac muscle cell apoptotic process IMP
IMP: Inferred from mutant phenotype
22044588 MGI
involved in positive regulation of pentose-phosphate shunt IDA
IDA: Inferred from direct assay
24872551 MGI
acts upstream of reactive oxygen species metabolic process IMP
IMP: Inferred from mutant phenotype
22044588 MGI
acts upstream of or within response to gamma radiation IMP
IMP: Inferred from mutant phenotype
23726973 MGI
involved in response to ischemia IDA
IDA: Inferred from direct assay
24872551 MGI
acts upstream of or within response to xenobiotic stimulus IMP
IMP: Inferred from mutant phenotype
23726973 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
24872551 MGI
located in mitochondrion IDA
IDA: Inferred from direct assay
24872551 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

fructose-2,6-bisphosphatase TIGAR

  • TP53-induced glycolysis and apoptosis regulator

  • TP53-induced glycolysis regulatory phosphatase

  • Trp53 induced glycolysis repulatory phosphatase

  • probable fructose-2,6-bisphosphatase TIGAR

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P1925A GO-203 TFA 98.39% Unkown
HY-RS14523 TIGAR Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18552 Tigar Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25034 Tigar Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tigar NCBI NCBI:57103