2. Gene
  3. TIGAR - TP53 induced glycolysis regulatory phosphatase Gene

TIGAR - TP53 induced glycolysis regulatory phosphatase Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as FR2BP; C12orf5

Gene ID: 57103 | Gene type: protein coding

About TIGAR

Cytogenetic location: 12p13.32 Genomic coordinates (GRCh38): 12:4,321,213-4,360,028 (from NCBI)

This gene has 4 transcripts (splice variants) and 108 orthologues. Ubiquitous expression in urinary bladder (RPKM 2.3), colon (RPKM 2.2) and 24 other tissues.

Summary

This gene is regulated as part of the p53 tumor suppressor pathway and encodes a protein with sequence similarity to the bisphosphate domain of the glycolytic Enzyme that degrades fructose-2,6-bisphosphate. The protein functions by blocking glycolysis and directing the pathway into the pentose phosphate shunt. Expression of this protein also protects cells from DNA damaging Reactive Oxygen Species and provides some protection from DNA damage-induced Apoptosis. The 12p13.32 region that includes this gene is paralogous to the 11q13.3 region. [provided by RefSeq, Jul 2008]

TIGAR Products(1)

mRNA Protein Name
NM_020375.3 NP_065108.1 fructose-2,6-bisphosphatase TIGAR

TIGAR Protein Structure

His_Phos_1

His_Phos_1: Histidine phosphatase superfamily (branch 1) (6 - 146)

  • 0
  • 100
  • 200
  • 270 a.a.
Protein Preferred Names Protein Names

fructose-2,6-bisphosphatase TIGAR

TP53-induced glycolysis and apoptosis regulator

Recombinant TIGAR Proteins

Cat. No. Product Name Accession Purity
HY-P71919 TIGAR Protein, Human (TAT) Q9NQ88 (M1-270R) ≥95%

Related Diseases

Diseases Alias
Hemangioma Of Spleen

Splenic Hemangioma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P1925A GO-203 TFA 99.28% Unkown
HY-RS14523 TIGAR Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus TIGAR MGD MGI:2442752
Rattus norvegicus TIGAR RGD RGD:1560038
Canis familiaris TIGAR VGNC VGNC:47368
Bos taurus TIGAR VGNC VGNC:35863
Macaca mulatta TIGAR VGNC VGNC:78374