HK2 - hexokinase 2 Gene

Also Known as HKII; HXK2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3099

About HK2

Cytogenetic location: 2p12 Genomic coordinates (GRCh38): 2:74,834,127-74,893,359 (from NCBI)

This gene has 3 transcripts (splice variants), 217 orthologues and 4 paralogues. Broad expression in fat (RPKM 34.4), colon (RPKM 24.2) and 19 other tissues.

Summary

Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes Hexokinase 2, the predominant form found in skeletal muscle. It localizes to the outer membrane of mitochondria. Expression of this gene is insulin-responsive, and studies in rat suggest that it is involved in the increased rate of glycolysis seen in rapidly growing Cancer cells. [provided by RefSeq, Apr 2009]

HK2 Products (2)

mRNA	Protein	Name
NM_000189.5	NP_000180.2	hexokinase-2 isoform 1
NM_001371525.1	NP_001358454.1	hexokinase-2 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables glucokinase activity	IDA IDA: Inferred from direct assay	29298880	GOA
enables hexokinase activity	IDA IDA: Inferred from direct assay	26985301	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within apoptotic mitochondrial changes	IDA IDA: Inferred from direct assay	18350175	GOA
involved in establishment of protein localization to mitochondrion	IMP IMP: Inferred from mutant phenotype	23962723	GOA
involved in glucose 6-phosphate metabolic process	IDA IDA: Inferred from direct assay	29298880	GOA
involved in maintenance of protein location in mitochondrion	IMP IMP: Inferred from mutant phenotype	23962723	GOA
involved in positive regulation of angiogenesis	IMP IMP: Inferred from mutant phenotype	25801897	GOA
involved in positive regulation of type 2 mitophagy	IMP IMP: Inferred from mutant phenotype	23962723	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in mitochondrial outer membrane	IDA IDA: Inferred from direct assay	18350175	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HK2 Protein Structure

Hexokinase_1

Hexokinase_2

Hexokinase_1

Hexokinase_2

0
200
400
600
800
917 a.a.

Protein Preferred Names	Protein Names
hexokinase-2	hexokinase type II

HK2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	HK2	P52789	UBQLN1	Homo sapiens	Q9UMX0-2	Validated Y2H	25416956
Intra	HK2	P52789	UBQLN1	Homo sapiens	Q9UMX0-2	Y2H Array	25416956
Intra	HK2	P52789	UBQLN1	Homo sapiens	Q9UMX0	Y2H Array	25416956
Intra	HK2	P52789	UBQLN1	Homo sapiens	Q9UMX0	Y2H Pooling	16189514
Intra	HK2	P52789	MAGEA12	Homo sapiens	P43365	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

HK2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80703	Hexokinase II Antibody (YA386)	WB, IHC-P, IP	Human, Rat, Hamster
HY-P80703A	Hexokinase II Antibody (YA386)(PBS only)	WB, IHC-P, IP	Human, Rat, Hamster
HY-P84385	Hexokinase II Antibody (YA4082)	WB, IHC-P, FC, ELISA	Human, Mouse, Rat, Rabbit
HY-P84385A	Hexokinase II Antibody (YA4082)(PBS only)	WB, IHC-P, FC, ELISA	Human, Mouse, Rat, Rabbit
HY-P86604	Hexokinase II Antibody (YA6296)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Pancreatic Cancer	Pancreatic Carcinoma Carcinoma Of Pancreas Familial Pancreatic Carcinoma Pancreatic Neoplasm Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Cancer Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Type 2 Diabetes Mellitus	Insulin Resistance NIDDM Type 2 Diabetes Diabetes Mellitus, Non-Insulin-Dependent T2D Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Type Ii Maturity-Onset Diabetes Insulin Resistance, Severe, Digenic Diabetes Mellitus, Type 2 Diabetes Mellitus, Noninsulin-Dependent Diabetes Mellitus, Noninsulin-Dependent, Association With Diabetes Mellitus, Noninsulin-Dependent, Late Onset Hypertension, Insulin Resistance-Related, Susceptibility To Insulin Resistance, Susceptibility To Non-Insulin-Dependent Diabetes Mellitus Type Ii Diabetes Mellitus Adult-Onset Diabetes Mellitus Maturity-Onset Diabetes Mellitus Diabetes Mellitus Type 2 Type Ii Diabetes Type 2 Diabetes Mellitus, Susceptibility To Diabetes, Type 2 Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 2, Susceptibility To Diabetes Mellitus, Noninsulin-Dependent, 2 Diabetes Mellitus, Type Ii, Susceptibility To Hypertension, Insulin Resistance-Related Adult-Onset Diabetes Aodm Diabetes Mellitus, Adult-Onset Diabetes Mellitus Type Ii Diabetes Mellitus Type 2, Susceptibility To Diabetes, Type Ii, Susceptibility To Diabetes Type 2 Diabetes Mellitus Adult Onset Diabetes Maturity Onset Diabetes Nonketotic Diabetes Non-Insulin Dependent Diabetes Mellitus T2dm - [Type 2 Diabetes Mellitus] Niddm - [Non Insulin Dependent Diabetes Mellitus] Dm2 Dm Type Ii Diabetic Type 2 Insulin Requiring Type 2 Diabetes Noninsulin Dependent Diabetes Non-Insulin-Dependent Diabetes Mellitus Without Complications Diabetes Due To Insulin Secretory Defect Diabetes Mellitus Due To Insulin Secretory Defect Non-Insulin-Dependent Diabetes Of The Young Senile Diabetes Nonketotic Hyperglycaemia Stable Diabetes
Hyperinsulinism	Hyperinsulinemia
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Carcinoma, Hepatocellular Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Diabetes Mellitus	Diabetes
Granulomatous Endometritis
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Body Mass Index Quantitative Trait Locus 11	OBESITY Obesity, Susceptibility To Leanness, Inherited Obesity, Susceptibility To, Bmiq11 Obesity, Mild, Early-Onset Obesity, Association With Obesity, Early-Onset, Susceptibility To Obesity, Severe Obesity, Severe, And Type Ii Diabetes Obesity, Late-Onset Obesity , Susceptibility To BMIQ11 Obesity Bmiq11 Obesity, Early-Onset Simple Obesity Nos Excess Fat Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified Adiposis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-101563	GSK3326595	Inhibitor	99.83%	Phase 2

Pre-clinical Phase

Bioactive Molecules (34)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-112780	UC2288		99.82%	Unkown
HY-155008	PROTAC HK2 Degrader-1	Degrader	99.76%	Unkown
HY-N0745	Senkyunolide I	Inhibitor	99.37%	Unkown
HY-N1990	Gypenoside XLIX		99.88%	Unkown
HY-N7675	Flavanomarein	Inhibitor	99.92%	Unkown
HY-155374	PP5-IN-1		99.47%	Unkown
HY-N8407	Carminic acid		95.19%	Unkown
HY-N2445	Flavokawain C		99.79%	Unkown
HY-125938	Cycloartenyl ferulate		99.15%	Unkown
HY-N0911	Rehmannioside A		99.95%	Unkown
HY-175035	HK-2-IN-1	Inhibitor	99.88%	Unkown
HY-W984782	Flindersine		99.80%	Unkown
HY-130437	p-nitro-Pifithrin-α		97.0%	Unkown
HY-156277	SP4f	Activator	99.77%	Unkown
HY-151432	URAT1 inhibitor 3	Inhibitor	98.02%	Unkown
HY-156276	SP4e	Activator	99.72%	Unkown
HY-RS07380	KLK2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-156368	RIPK3-IN-4	Inhibitor	/	Unkown
HY-15947G	Ravoxertinib (GMP)	Inhibitor	/	Unkown
HY-168717	HK-2-IN-2	Inhibitor	/	Unkown
HY-179378	XRF-1021	Inhibitor	/	Unkown
HY-180805	HK2-IN-3		/	Unkown
HY-181652	PPARδ agonist 13	Agonist	/	Unkown
HY-182243	HK2-IN-4		/	Unkown
HY-183809	ZSW	Inhibitor	/	Unkown
HY-184282	Mitochondrial complex I-IN-1		/	Unkown
HY-P4890	Relaxin H3 (human)		/	Unkown
HY-RS06193	HK2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS06288	HOOK2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS07101	KCNA5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS07282	KIF2A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-111331	Germicidin B	Inhibitor	/	Unkown
HY-RS16576	Hk2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23009	Hk2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P991808	Anti-Mouse CD90 Antibody (HK2.1)	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	HK2	VGNC	VGNC:73475
Rattus norvegicus	HK2	RGD	RGD:2797
Canis familiaris	HK2	VGNC	VGNC:41699
Felis catus	HK2	VGNC	VGNC:67580
Mus musculus	HK2	MGD	MGI:1315197
Bos taurus	HK2	VGNC	VGNC:29865
Others	HK2	NCBI