Cecr2 - CECR2, histone acetyl-lysine reader Gene

Also Known as Gtl4; 2610101O16Rik; 2810409N01Rik

生物種: Mus musculus

遺伝子タイプ: protein coding
遺伝子ID: 330409

About Cecr2

Chromosome 6: 120,643,330-120,748,151 forward strand.GRCm39:CM000999.3

This gene has 8 transcripts (splice variants), 156 orthologues, 11 paralogues and is associated with 24 phenotypes. Ubiquitous expression in testis adult (RPKM 4.5), CNS E11.5 (RPKM 4.) and 23 other tissues.

Summary

Predicted to enable ATP-dependent chromatin remodeler activity. Acts upstream of or within inner ear development; primary neural tube formation; and single fertilization. Located in euchromatin. Part of ISWI-type complex. Is expressed in several structures, including extraembryonic component; genitourinary system; and olfactory epithelium. Used to study anencephaly. Orthologous to human CECR2 (CECR2 histone acetyl-lysine reader). [provided by Alliance of Genome Resources, Apr 2022]

Cecr2 Products (2)

mRNA Protein Name
NM_001368706.1 NP_001355635.1 chromatin remodeling regulator CECR2 isoform 2
NM_001128151.2 NP_001121623.1 chromatin remodeling regulator CECR2 isoform 1

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence 参考文献 由来
acts upstream of or within cochlea development IMP
IMP: Inferred from mutant phenotype
21246654 MGI
acts upstream of or within inner ear receptor cell stereocilium organization IMP
IMP: Inferred from mutant phenotype
21246654 MGI
acts upstream of or within neural fold formation IMP
IMP: Inferred from mutant phenotype
21246654 MGI
acts upstream of or within neural tube closure IGI
IGI: Inferred from genetic interaction
21246654 MGI
acts upstream of or within neural tube closure IMP
IMP: Inferred from mutant phenotype
15640247 MGI
acts upstream of or within neural tube development IMP
IMP: Inferred from mutant phenotype
22045912 MGI
acts upstream of or within single fertilization IMP
IMP: Inferred from mutant phenotype
22154806 MGI
Cellular Component GO Annotation Evidence 参考文献 由来
part of ISWI-type complex IPI
IPI: Inferred from physical interaction
22154806 MGI
located in euchromatin IDA
IDA: Inferred from direct assay
9701556 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Cecr2 Protein Structure

Bromo_gcn5_like

Bromo_gcn5_like: cd05509 (417 - 517)

PHA03247

PHA03247: cl33720 (557 - 1030)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1453 a.a.
Protein Preferred Names Protein Names

chromatin remodeling regulator CECR2

cat eye syndrome critical region protein 2 homolog

  • cat eye syndrome chromosome region, candidate 2 homolog

  • gene trap locus 4

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-110374 NVS-CECR2-1 Inhibitor 99.40% Unkown
HY-112610 CF53 Inhibitor 99.81% Unkown
HY-114205A TP-238 hydrochloride Inhibitor ≥99.0% Unkown
HY-114205 TP-238 Inhibitor / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Homo sapiens Cecr2 NCBI NCBI:27443