2. Epigenetics
  3. Epigenetic Reader Domain
  4. TP-238

TP-238 is a potent and selective dual CECR2/BPTF probe with IC50 values of 30 nM and 350 nM, respectively. TP-238 also inhibits BRD9 with a pIC50 of 5.9 and is less active against other 338 kinases.

At equivalent molar concentrations, both the salt and free forms of a compound exhibit comparable biological activity. Nevertheless, the salt form (TP-238 hydrochloride) usually boasts enhanced water solubility and stability.

For research use only. We do not sell to patients.

TP-238 Chemical Structure

TP-238 Chemical Structure

CAS No. : 2415263-04-4

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TP-238 Related Antibodies

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Description

TP-238 is a potent and selective dual CECR2/BPTF probe with IC50 values of 30 nM and 350 nM, respectively. TP-238 also inhibits BRD9 with a pIC50 of 5.9 and is less active against other 338 kinases[1][2].

IC50 & Target[1][2]

CECR2

30 nM (IC50)

CECR2

10 nM (Kd)

CECR2

7.5 (pIC50)

BPTF

350 nM (IC50)

BPTF

120 nM (Kd)

BPTF

6.5 (pIC50)

BRD9

5.9 (pIC50)

In Vitro

TP-238 has on target biochemical activity of 10-30 nM with CECR2 and 100-350 nM with BPTF. TP-238 displays potency for both CECR2 (pIC50 of 7.5) and BPTF (pIC50 of 6.5) in an Alpha screen assay. Isothermal titration calorimetry (ITC) shows TP-238 with a Kd of 10 nM for CECR2 and 120 nM for BPTF[1][2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

TP-238 Related Antibodies
Molecular Weight

458.58

Formula

C22H30N6O3S
CAS No.
SMILES

CN(C)CCCOC1=CC=C(C=C1)C2=CC(NCCCN3N=CC=C3)=NC(S(=O)(C)=O)=N2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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TP-238 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TP-2382415263-04-4TP238TP 238Epigenetic Reader DomainCECR2BPTFBRD9probeoff-targetInhibitorinhibitorinhibit

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