1. Epigenetics
  2. Epigenetic Reader Domain
  3. TP-238

TP-238 

Cat. No.: HY-114205
Handling Instructions

TP-238 is a potent and selective dual CECR2/BPTF probe with pIC50 values of 7.5 and 6.5, respectively. TP-238 also inhibits BRD9 with a pIC50 of 5.9 and is less active against other 338 kinases.

For research use only. We do not sell to patients.

TP-238 Chemical Structure

TP-238 Chemical Structure

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Description

TP-238 is a potent and selective dual CECR2/BPTF probe with pIC50 values of 7.5 and 6.5, respectively. TP-238 also inhibits BRD9 with a pIC50 of 5.9 and is less active against other 338 kinases[1][2].

IC50 & Target[1]

CECR2

7.5 (pIC50)

BPTF

6.5 (pIC50)

BRD9

5.9 (pIC50)

In Vitro

TP-238 (compound 4) has on target biochemical activity of 10-30 nM with CECR2 and 100-350 nM with BPTF. TP-238 shows an IC50 of 30 nM against CECR2 and 350 nM against BPTF in an alphascreen assay. ITC shows TP-238 with a Kd of 10 nM for CECR2 and 120 nM for BPTF[1][2].

Molecular Weight

458.58

Formula

C₂₂H₃₀N₆O₃S

SMILES

CN(C)CCCOC1=CC=C(C=C1)C2=CC(NCCCN3N=CC=C3)=NC(S(=O)(C)=O)=N2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

TP-238TP238TP 238Epigenetic Reader DomainCECR2BPTFBRD9probeoff-targetInhibitorinhibitorinhibit

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TP-238
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