HTR1E - 5-hydroxytryptamine receptor 1E Gene

Also Known as 5-HT1E

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3354

About HTR1E

Cytogenetic location: 6q14.3 Genomic coordinates (GRCh38): 6:86,937,528-87,016,679 (from NCBI)

This gene has 1 transcript (splice variant), 158 orthologues and 8 paralogues. Biased expression in ovary (RPKM 1.3), endometrium (RPKM 0.7) and 4 other tissues.

Summary

Enables G protein-coupled serotonin receptor activity and serotonin binding activity. Involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway. Is integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

HTR1E Products (1)

mRNA Protein Name
NM_000865.3 NP_000856.1 5-hydroxytryptamine receptor 1E

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables G protein-coupled serotonin receptor activity IDA
IDA: Inferred from direct assay
1608964 GOA
enables G protein-coupled serotonin receptor activity IMP
IMP: Inferred from mutant phenotype
21422162 GOA
enables Gi/o-coupled serotonin receptor activity IDA
IDA: Inferred from direct assay
33762731 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
enables serotonin binding IDA
IDA: Inferred from direct assay
1608964 GOA
enables serotonin receptor activity IDA
IDA: Inferred from direct assay
33762731 GOA
Biological Process GO Annotation Evidence References Source
involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
21422162 GOA
involved in adenylate cyclase-inhibiting serotonin receptor signaling pathway IDA
IDA: Inferred from direct assay
33762731 GOA
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IMP
IMP: Inferred from mutant phenotype
21422162 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HTR1E Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (40 - 344)

  • 0
  • 100
  • 200
  • 300
  • 365 a.a.
Protein Preferred Names Protein Names

5-hydroxytryptamine receptor 1E

  • 5-HT-1E

HTR1E Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
HTR1E P28566 ATP5F1B Homo sapiens P06576
Anti Tag CoIP
33961781
Intra
HTR1E P28566 ATP5F1B Homo sapiens P06576
Anti Tag CoIP
28514442
Intra
HTR1E P28566 MEOX2 Homo sapiens P50222
Y2H Array
25416956
Intra
HTR1E P28566 MEOX2 Homo sapiens P50222
Y2H Prey Pooling
25416956
Intra
HTR1E P28566 MEOX2 Homo sapiens P50222
Validated Y2H
25416956
Intra
HTR1E P28566 OPTN Homo sapiens Q96CV9
Y2H Array
32814053
Intra
HTR1E P28566 OPTN Homo sapiens Q96CV9
Y2H Pooling
32814053
Intra
HTR1E P28566 OPTN Homo sapiens Q96CV9
Validated Y2H
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Ocular Hypotension

  • Hypotony Of Eye
Migraine With Or Without Aura 1

  • Migraine

  • Migraine With Or Without Aura, Susceptibility To, 1

  • Migraine Disorder

  • Migraine Variant

  • Migraines

  • Migraine Disorders

  • Mgr1

  • Mgau

  • Ma

  • Migraine With Or Without Aura

  • Classic Migraine

  • Common Migraine

  • Disorder, Migraine

  • Headache Migraine

  • Headache Migrainous

  • Migraine Headache

  • Migraine Syndrome

  • Headache Including Migraine

  • Migraine, Susceptibility To
Attention Deficit-Hyperactivity Disorder

  • Attention Deficit Hyperactivity Disorder

  • ADHD

  • Attention Deficit Disorder

  • Attention Deficit-Hyperactivity Disorder, Susceptibility To

  • Attention Deficit Disorder With Hyperactivity

  • Hyperkinetic Disorder

  • Hyperactivity Of Childhood

  • Attention-Deficit/Hyperactivity Disorder

  • Add

  • Addh

  • Attention Deficit

  • Attention Deficit Disorder Of Childhood With Hyperactivity

  • Attention Deficit Disorder With Hyperactivity Syndrome

  • Hyperkinetic Syndrome

  • Attention-Deficit Hyperactivity Disorder

  • Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type

  • Disturbance Of Activity And Attention

  • Disorder Of Activity And Attention

  • Adhd - [Attention Deficit Hyperactivity Disorder]

  • Hyperkinetic Disorders

  • Disorder Of Activity And Attention With Hyperkinesia

  • Attention Deficit Syndrome With Hyperactivity
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06463 HTR1E Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22563 Htr1e Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown