LINGO4 - leucine rich repeat and Ig domain containing 4 Gene

Also Known as LRRN6D; DAAT9248; PRO34002

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 339398

About LINGO4

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:151,800,264-151,805,419 (from NCBI)

This gene has 1 transcript (splice variant), 367 orthologues and 10 paralogues. Broad expression in adrenal (RPKM 1.2), testis (RPKM 0.4) and 16 other tissues.

Summary

Predicted to act upstream of or within positive regulation of synapse assembly. Predicted to be integral component of membrane. Predicted to be active in extracellular matrix and extracellular space. [provided by Alliance of Genome Resources, Apr 2022]

LINGO4 Products (1)

mRNA	Protein	Name
NM_001004432.4	NP_001004432.1	leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 4 precursor

LINGO4 Protein Structure

LRR_8

I-set

0
100
200
300
400
500
593 a.a.

Protein Preferred Names	Protein Names
leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 4	leucine-rich repeat neuronal protein 6D

Related Diseases

Diseases	Alias
Essential Tremor	Benign Essential Tremor Familial Tremor Hereditary Essential Tremor Essential Hereditary Tremor Shaky Hand Syndrome Benign Essential Tremor Syndrome Tremor Hereditary Essential Essential Tremor, Susceptibility To Tremor, Hereditary Essential
Tremor, Hereditary Essential, 5	ETM5 Essential Tremor 5 Essential Tremor, Hereditary, 5 Hereditary Essential Tremor 5 Tremor, Hereditary Essential 5 Tremor, Essential Hereditary, Type 5
Tremor, Hereditary Essential, 4	ETM4 Essential Tremor 4 Essential Tremor, Hereditary, 4 Hereditary Essential Tremor 4 Tremor, Hereditary Essential 4 Tremor, Hereditary Essential, Type 4

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07683	LINGO4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	LINGO4	VGNC	VGNC:63238
Bos taurus	LINGO4	VGNC	VGNC:30902
Mus musculus	LINGO4	MGD	MGI:2444651
Macaca mulatta	LINGO4	VGNC	VGNC:74171
Canis familiaris	LINGO4	VGNC	VGNC:42691
Rattus norvegicus	LINGO4	RGD	RGD:1562025
Others	LINGO4	NCBI