OR2AT4 - olfactory receptor family 2 subfamily AT member 4 Gene
Also Known as OR11-265
Species: Homo sapiens
About OR2AT4
This gene has 5 transcripts (splice variants), 63 orthologues and 130 paralogues. Low expression observed in reference dataset.
Summary
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The Olfactory Receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The Olfactory Receptor gene family is the largest in the genome. The nomenclature assigned to the Olfactory Receptor genes and proteins for this organism is independent of Other organisms. [provided by RefSeq, Jul 2008]
OR2AT4 Products (2)
| mRNA | Protein | Name |
|---|---|---|
| NM_001005285.2 | NP_001005285.1 | olfactory receptor 2AT4 isoform 1 |
| NM_001405852.1 | NP_001392781.1 | olfactory receptor 2AT4 isoform 1 |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables olfactory receptor activity |
IDA
IDA: Inferred from direct assay
|
24999593 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in positive regulation of ERK1 and ERK2 cascade |
IMP
IMP: Inferred from mutant phenotype
|
24999593 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in plasma membrane |
IDA
IDA: Inferred from direct assay
|
24999593 | GOA |
OR2AT4 Protein Structure
7tm_1: 7 transmembrane receptor (rhodopsin family) (46 - 295)
- 0
- 100
- 200
- 300
- 320 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
olfactory receptor 2AT4 |
|
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Telogen Effluvium |
|
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| Diffuse Alopecia Areata |
|
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| Lymph Node Carcinoma |
|
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Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Rattus norvegicus | OR2AT4 | RGD | RGD:1333428 |
| Mus musculus | OR2AT4 | MGD | MGI:3030354 |
| Others | OR2AT4 | NCBI |