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FCRL6 - Fc receptor like 6 Gene

Also Known as FcRH6

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 343413

About FCRL6

Cytogenetic location: 1q23.2 Genomic coordinates (GRCh38): 1:159,800,512-159,816,257 (from NCBI)

This gene has 7 transcripts (splice variants), 149 orthologues and 17 paralogues. Broad expression in spleen (RPKM 6.7), lung (RPKM 2.6) and 14 other tissues.

Summary

Enables MHC class II protein binding activity and protein Phosphatase binding activity. Predicted to be involved in cell surface receptor signaling pathway. Located in external side of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

FCRL6 Products (2)

mRNA	Protein	Name
NM_001004310.3	NP_001004310.2	Fc receptor-like protein 6 isoform 1 precursor
NM_001284217.2	NP_001271146.1	Fc receptor-like protein 6 isoform 2

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables MHC class II protein binding	IDA IDA: Inferred from direct assay	20519654	GOA
enables phosphatase binding	IPI IPI: Inferred from physical interaction	20933011	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	20933011	GOA
enables protein phosphatase binding	IPI IPI: Inferred from physical interaction	20933011	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	17213291	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	18991291	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FCRL6 Protein Structure

Ig_2

Ig_3

0
100
200
300
400
434 a.a.

Protein Preferred Names	Protein Names
Fc receptor-like protein 6	Fc receptor-like protein 7

FCRL6 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	FCRL6	Q6DN72	GALNT15	Homo sapiens	Q8N3T1	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant FCRL6 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71565	FCRL6 Protein, Human (His)	Q6DN72-1 (L20-W307)	≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Clear Cell Adenoma
Breast Medullary Carcinoma	Medullary Breast Carcinoma Medullary Breast Carcinoma With Lymphoid Stroma Medullary Carcinoma Of Breast
Severe Combined Immunodeficiency	Scid Severe Combined Immunodeficiency Disease Combined T And B Cell Inborn Immunodeficiency Immunodeficiency, Severe Combined Scid - [Severe Combined Immunodeficiencies]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04847	FCRL6 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20018	Fcrl6 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26521	Fcrl6 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	FCRL6	VGNC	VGNC:55190
Rattus norvegicus	FCRL6	RGD	RGD:1563939
Macaca mulatta	FCRL6	VGNC	VGNC:72602
Mus musculus	FCRL6	MGD	MGI:3618339
Others	FCRL6	NCBI