CCN1 - cellular communication network factor 1 Gene

Also Known as GIG1; CYR61; IGFBP10

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3491

About CCN1

Cytogenetic location: 1p22.3 Genomic coordinates (GRCh38): 1:85,580,761-85,583,950 (from NCBI)

This gene has 6 transcripts (splice variants), 255 orthologues and 5 paralogues. Broad expression in gall bladder (RPKM 285.2), spleen (RPKM 216.9) and 20 other tissues.

Summary

The secreted protein encoded by this gene is growth factor-inducible and promotes the adhesion of endothelial cells. The encoded protein interacts with several integrins and with heparan sulfate proteoglycan. This protein also plays a role in cell proliferation, differentiation, angiogenesis, Apoptosis, and extracellular matrix formation. [provided by RefSeq, Sep 2011]

CCN1 Products (1)

mRNA	Protein	Name
NM_001554.5	NP_001545.2	CCN family member 1 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of BMP signaling pathway	IGI IGI: Inferred from genetic interaction	20675382	GOA
involved in positive regulation of bone mineralization	IDA IDA: Inferred from direct assay	20675382	GOA
involved in positive regulation of cell migration	IDA IDA: Inferred from direct assay	20675382	GOA
involved in positive regulation of osteoblast differentiation	IDA IDA: Inferred from direct assay	20675382	GOA
involved in positive regulation of osteoblast proliferation	IDA IDA: Inferred from direct assay	20675382	GOA
involved in positive regulation of protein kinase activity	IDA IDA: Inferred from direct assay	20675382	GOA
involved in positive regulation of protein phosphorylation	IDA IDA: Inferred from direct assay	20675382	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	20675382	GOA
involved in regulation of ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	20675382	GOA
involved in wound healing, spreading of cells	IDA IDA: Inferred from direct assay	20675382	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CCN1 Protein Structure

IGFBP

VWC

TSP_1

Cys_knot

0
100
200
300
381 a.a.

Protein Preferred Names	Protein Names
CCN family member 1	IBP-10

CCN1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CCN1	O00622	SMPD2	Homo sapiens	O60906	Validated Y2H	32296183
Intra	CCN1	O00622	SMPD2	Homo sapiens	O60906	Y2H Prey Pooling	32296183
Intra	CCN1	O00622	SMPD2	Homo sapiens	O60906	Y2H Array	32296183
Intra	CCN1	O00622	UBQLN2	Homo sapiens	Q9UHD9	Y2H Array	32296183
Intra	CCN1	O00622	UBQLN2	Homo sapiens	Q9UHD9	Y2H Prey Pooling	32296183
Intra	CCN1	O00622	UBQLN2	Homo sapiens	Q9UHD9	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CCN1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7842	CCN1/Cyr61 Protein, Human (HEK293, Fc)	O00622 (T25-D381)	≥ 90%, as determined by reducing SDS-PAGE.

CCN1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P86830	CYR61/CCN1 Antibody (YA6523)	WB, ICC/IF, IHC-P, IF-Tissue	Human

Related Diseases

Diseases	Alias
Wilms Tumor 5	Wilms Tumor WT5 Wilms Tumor Susceptibility-5 Wilms Tumor And Radial Bilateral Aplasia Nephroblastoma Wilms' Tumor Wilms Tumor, Susceptibility To Wtsl Bilateral Radial Aplasia With Wilms Tumor Embryonal Adenosarcoma Embryonal Nephroma Kidney Wilms Tumor Kidney, Adenomyosarcoma, Embryonal Kidney, Carcinosarcoma, Embryonal Kidney, Embryoma Kidney, Embryonal Mixed Tumor Nephroma Renal Adenosarcoma Renal Cancer, Wilms Renal Wilms Tumor Tumor, Wilms Hereditary Susceptibility To Wilms Tumor 5
Endometriosis	Endometriosis, Site Unspecified Endometrial Ectopia
Rhabdomyosarcoma
Endometrial Cancer	Endometrial Carcinoma Endometrial Neoplasm Malignant Neoplasm Of Endometrium Endometrioid Carcinoma Endometrial Neoplasms Carcinoma, Endometrioid Endometrial Cancer, Familial Endometrial Carcinoma, Somatic Endometrial Cancer, Susceptibility To Endometrial Ca Malignant Endometrial Neoplasm Neoplasm Of Endometrium Primary Malignant Neoplasm Of Endometrium Tumor Of Endometrium Carcinoma Of The Endometrium Endometrioid Carcinoma Of Female Reproductive System ENDMC Carcinoma Endometrioid Endometrial Cancers Cancer, Endometrial Uterine Corpus Cancer
Progressive Pseudorheumatoid Dysplasia	Progressive Pseudorheumatoid Arthropathy Of Childhood Arthropathy, Progressive Pseudorheumatoid, Of Childhood Spondyloepiphyseal Dysplasia Tarda With Progressive Arthropathy Ppd Ppac Sedt-Pa Spondyloepiphyseal Dysplasia Tarda-Progressive Arthropathy Syndrome PPRD Progressive Pseudorheumatoid Chondrodysplasia Spondyloepiphyseal Dysplasia Tarda - Progressive Arthropathy Spondyloepiphyseal Dysplasia Tarda With Progressive Arthropathy Dysplasia, Pseudorheumatoid, Progressive
Renal Fibrosis
Melanoma, Uveal	Uveal Melanoma Choroidal Melanoma Melanoma Of Uvea Iris Melanoma Malignant Melanoma Of Choroid Malignant Melanoma Of Iris
Pre-Eclampsia	Preeclampsia Gestational Hypertension Hypertension Induced By Pregnancy Pre-Eclamptic Toxaemia Pregnancy Associated Hypertension Proteinuric Hypertension Of Pregnancy Hypertension, Pregnancy-Induced, Susceptibility To Preeclampsia/Eclampsia Pregnancy Toxemia Toxaemia Of Pregnancy Gestational Proteinuric Hypertension Pregnancy-Induced Hypertension Toxemia Of Pregnancy Preeclampsia, Susceptibility To Transient Hypertension Of Pregnancy Gestational [Pregnancy-Induced] Hypertension Without Significant Proteinuria Gestational Hypertension Nos Mild Proteinuric Hypertension Of Pregnancy Pih - [Pregnancy-Induced Hypertension] Pregnancy-Induced Hypertension Nos Gestational [Pregnancy-Induced] Hypertension With Significant Proteinuria Pe - [Pre-Eclampsia] Pre-Eclampsia Nos Pre-Eclamptic Nos Pregnancy Pre-Eclampsia Puerperal Pre-Eclampsia Pre-Eclampsia Toxaemia Toxaemia In Pregnancy Pet - [Pre-Eclamptic Toxaemia] Maternal Toxaemia
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Gastric Cancer	Stomach Cancer Gastric Carcinoma Stomach Carcinoma Gastric Cancer, Somatic Gastric Neoplasm Carcinoma Of Stomach Stomach Neoplasms Malignant Neoplasm Of Stomach Gastric Cancer Risk After H. Pylori Infection Cancer Of The Stomach Adult Stomach Cancer Adult Stomach Carcinoma GASC Gastric Cancer Intestinal Gastric Cancers Gastric Carcinomas Cancer, Gastric Stomach Neoplasm Malignant Neoplasm Of Body Of Stomach Malignant Tumor Of Lesser Curve Of Stomach Gastrocarcinoma Of Unspecified Site Leather Bottle Stomach Carcinoma Of Fundus Of Stomach Cancer Of Fundus Of Stomach Primary Malignant Neoplasm Of Body Of Stomach Cancer Of Body Of Stomach Primary Malignant Neoplasm Of Pyloric Antrum Pyloric Antrum Cancer Malignant Tumour Of Stomach
Wilms Tumor 1	Nephroblastoma Wilms Tumor WT1 Wilms' Tumor Bilateral Wilms Tumor Wilms Tumor, Type 1 Wilms Tumor, Somatic Adult Nephroblastoma Wt1 Disorder Renal Embryonic Tumor Adult Kidney Wilms Tumor Childhood Kidney Wilms Tumor Nonanaplastic Kidney Wilms Tumor

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02117	CCNA2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-181537	PROTAC TEAD1/IAP degrader-2		/	Unkown
HY-184179	TEAD degrader-1	Degrader	/	Unkown
HY-RS02110	CCN1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS11023	PPP3CA Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17949	Ccn1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18168	Ccna2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24420	Ccn1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	CCN1	VGNC	VGNC:50294
Rattus norvegicus	CCN1	RGD	RGD:620763
Mus musculus	CCN1	MGD	MGI:88613
Bos taurus	CCN1	VGNC	VGNC:50270
Felis catus	CCN1	VGNC	VGNC:60546
Macaca mulatta	CCN1	VGNC	VGNC:70874
Others	CCN1	NCBI