IGHA1 - immunoglobulin heavy constant alpha 1 Gene

Also Known as IgA1

Species: Homo sapiens

Gene Type: other
Gene ID: 3493

About IGHA1

Cytogenetic location: 14q32.33 Genomic coordinates (GRCh38): 14:105,707,168-105,708,664 (from NCBI)

This gene has 2 transcripts (splice variants), 1 gene allele, 87 orthologues and 82 paralogues.

Summary

Contributes to immunoglobulin receptor binding activity. Involved in Antibacterial humoral response; glomerular filtration; and positive regulation of respiratory burst. Located in extracellular space. Part of monomeric IgA immunoglobulin complex and secretory dimeric IgA immunoglobulin complex. [provided by Alliance of Genome Resources, Apr 2022]

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
contributes to immunoglobulin receptor binding IDA
IDA: Inferred from direct assay
23250751 GOA
Biological Process GO Annotation Evidence References Source
involved in antibacterial humoral response IDA
IDA: Inferred from direct assay
23250751 GOA
involved in glomerular filtration IMP
IMP: Inferred from mutant phenotype
23398317 GOA
involved in positive regulation of respiratory burst IDA
IDA: Inferred from direct assay
24145934 GOA
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
23398317 GOA
part of monomeric IgA immunoglobulin complex IDA
IDA: Inferred from direct assay
23250751 GOA
part of secretory IgA immunoglobulin complex IDA
IDA: Inferred from direct assay
23250751 GOA
part of secretory dimeric IgA immunoglobulin complex IDA
IDA: Inferred from direct assay
24145934 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IGHA1 Protein Structure

C1-set

C1-set: Immunoglobulin C1-set domain (17 - 94)

Ig_2

Ig_2: Immunoglobulin domain (139 - 213)

C1-set

C1-set: Immunoglobulin C1-set domain (235 - 321)

  • 0
  • 100
  • 200
  • 300
  • 353 a.a.

IGHA1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P83914 IghA1 Antibody (YA3611) WB, IHC-P, ICC/IF, FC, ELISA Human, Mouse, Monkey
HY-P83914A IghA1 Antibody (YA3611)(PBS only) WB, IHC-P, ICC/IF, FC, ELISA Human, Mouse, Monkey

Related Diseases

Diseases Alias
Retinitis Pigmentosa

  • RP

  • Rod-Cone Dystrophy

  • Autosomal Recessive Retinitis Pigmentosa

  • Non-Syndromic Retinitis Pigmentosa

  • Pericentral Pigmentary Retinopathy

  • Pigmentary Retinopathy

  • Tapetoretinal Degeneration

  • Rcd

  • Retinitis Pigmentosa Autosomal Recessive

  • ARRP

  • Retinitis Pigmentosa, Autosomal Recessive

  • Retinitis Pigmentosa 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Mus musculus IGHA1 MGD MGI:96444