Gars - glycyl-tRNA synthetase Gene

Also Known as Gars1; Nmf249; Sgrp23; GENA202; Gena201

Species: Mus musculus

Gene Type: protein coding
Gene ID: 353172

Summary

Enables glycine-tRNA Ligase activity. Acts upstream of or within glycyl-tRNA aminoacylation. Located in extracellular exosome and secretory granule. Is expressed in several structures, including alimentary system; cardiovascular system; nervous system; respiratory system; and urinary system. Used to study Charcot-Marie-Tooth disease type 2D. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 2D and distal hereditary motor neuronopathy type 5A. Orthologous to human GARS1 (glycyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Apr 2022]

Gars Products (1)

mRNA Protein Name
NM_180678.3 NP_851009.2 glycine--tRNA ligase

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables glycine-tRNA ligase activity IMP
IMP: Inferred from mutant phenotype
19470612 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
8939962 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within glycyl-tRNA aminoacylation IMP
IMP: Inferred from mutant phenotype
19470612 MGI
Cellular Component GO Annotation Evidence References Source
located in extracellular exosome IDA
IDA: Inferred from direct assay
26503042 MGI
located in secretory granule IDA
IDA: Inferred from direct assay
8939962 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

glycine--tRNA ligase

  • AP-4-A synthetase

  • ap4A synthetase

  • diadenosine tetraphosphate synthetase

  • glyRS

  • glycyl-tRNA synthetase 1

  • storage granule protein 23

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0117 Tigecycline 99.95% Yes
HY-B0117D Tigecycline hydrate 99.51% Unkown
HY-B0117A Tigecycline hydrochloride 99.56% Yes
HY-B0117C Tigecycline tetramesylate 97.01% Yes
HY-B0117B Tigecycline mesylate / Unkown
HY-B0117R Tigecycline (Standard) / Unkown

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-B0117S Tigecycline-d9 98.2% Unkown
HY-117058 LY243246 / Unkown
HY-14526 5-DACTHF Inhibitor / Unkown
HY-RS05277 GAR1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05279 GARS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05280 GART Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19198 Gars1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25686 Gars1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown