IRF2BP2 - interferon regulatory factor 2 binding protein 2 Gene

Also Known as CVID14

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 359948

About IRF2BP2

Cytogenetic location: 1q42.3 Genomic coordinates (GRCh38): 1:234,604,269-234,610,178 (from NCBI)

This gene has 3 transcripts (splice variants), 260 orthologues, 5 paralogues and is associated with 3 phenotypes. Ubiquitous expression in bone marrow (RPKM 91.3), thyroid (RPKM 43.5) and 25 other tissues.

Summary

This gene encodes an interferon regulatory factor-2 (IRF2) binding protein that interacts with the C-terminal transcriptional repression domain of IRF2. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

IRF2BP2 Products (2)

mRNA Protein Name
NM_001077397.1 NP_001070865.1 interferon regulatory factor 2-binding protein 2 isoform B
NM_182972.3 NP_892017.2 interferon regulatory factor 2-binding protein 2 isoform A

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables transcription corepressor activity IDA
IDA: Inferred from direct assay
12799427 GOA
Biological Process GO Annotation Evidence References Source
involved in immature B cell differentiation IDA
IDA: Inferred from direct assay
27016798 GOA
acts upstream of or within negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
12799427 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
12799427 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IRF2BP2 Protein Structure

IRF-2BP1_2

IRF-2BP1_2: Interferon regulatory factor 2-binding protein zinc finger (11 - 64)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 587 a.a.
Protein Preferred Names Protein Names

interferon regulatory factor 2-binding protein 2

  • IRF-2-binding protein 2

Related Diseases

Diseases Alias
Immunodeficiency, Common Variable, 14

  • CVID14

  • Common Variable Immunodeficiency 14
Common Variable Immunodeficiency

  • Cvid

  • Common Variable Agammaglobulinemia

  • Common Variable Immune Deficiency

  • Acquired Hypogammaglobulinemia

  • Hypogamma-Globulinemia, Acquired

  • Idiopathic Immunoglobulin Deficiency

  • Primary Antibody Deficiency

  • Primary Hypogammaglobulinemia

  • Acquired Agammaglobulinemia

  • Sporadic Hypogammaglobulinemia

  • Common Variable Hypogamma-Globulinemia

  • Immunoglobulin Deficiency, Late-Onset

  • Common Variable Hypogammaglobulinemia

  • Immunodeficiency, Common Variable
Acute Promyelocytic Leukemia

  • Leukemia, Acute Promyelocytic

  • Acute Myeloblastic Leukemia Type 3

  • Aml M3

  • APL

  • Leukemia, Acute Promyelocytic, Somatic

  • Aml With T(15

  • 17)(Q22

  • Q12)

  • (Pml/Raralpha) And Variants

  • Apml

  • Acute Myeloblastic Leukemia 3

  • Acute Myeloid Leukemia With T(15

  • 17)(Q22

  • Q12)

  • (Pml/Raralpha) And Variants

  • Acute Myeloblastic Leukaemia Type 3

  • Acute Myeloid Leukaemia M3

  • Acute Myeloid Leukemia M3

  • Acute Promyelocytic Leukaemia

  • M3 Anll

  • Myeloid Leukemia, Acute, M3

  • Leukemia Promyelocytic Acute

  • Leukemia, Promyelocytic, Acute

  • Leukemia, Acute, Promyelocytic
Mesenchymal Chondrosarcoma

  • Chondrosarcoma, Mesenchymal

  • Chondrosarcoma Mesenchymal
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06905 IRF2BP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus IRF2BP2 MGD MGI:2443921
Rattus norvegicus IRF2BP2 RGD RGD:1589517
Bos taurus IRF2BP2 VGNC VGNC:30272
Canis familiaris IRF2BP2 VGNC VGNC:51901
Macaca mulatta IRF2BP2 VGNC VGNC:106391
Others IRF2BP2 NCBI