Top2a - DNA topoisomerase II alpha Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 360243

About Top2a

Primary_assembly 10: 83,945,735-83,976,874 reverse strand.mRatBN7.2:CM026983.1

This gene has 3 transcripts (splice variants), 205 orthologues, 1 paralogue and is associated with 25 phenotypes. Biased expression in Thymus (RPKM 915.5), Spleen (RPKM 349.2) and 6 other tissues.

Summary

Enables several functions, including ATP binding activity; DNA Topoisomerase type II (double strand cut, ATP-hydrolyzing) activity; and chromatin binding activity. Involved in several processes, including DNA topological change; cerebellar cortex formation; and response to parathyroid hormone. Located in nucleolus. Part of DNA Topoisomerase type II (double strand cut, ATP-hydrolyzing) complex. Orthologous to human TOP2A (DNA Topoisomerase II alpha). [provided by Alliance of Genome Resources, Apr 2022]

Top2a Products (1)

mRNA Protein Name
NM_001393768.1 NP_001380697.1 DNA topoisomerase 2-alpha

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ATP binding IDA
IDA: Inferred from direct assay
11334111 RGD
enables DNA binding IDA
IDA: Inferred from direct assay
11334111 RGD
enables DNA topoisomerase activity IDA
IDA: Inferred from direct assay
11334111 RGD
enables DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity IDA
IDA: Inferred from direct assay
11334111 RGD
enables chromatin binding IDA
IDA: Inferred from direct assay
11334111 RGD
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
11334111 RGD
Biological Process GO Annotation Evidence References Source
involved in DNA topological change IDA
IDA: Inferred from direct assay
11334111 RGD
involved in cerebellar Purkinje cell differentiation IEP
IEP: Inferred from expression pattern
11170002 RGD
involved in cerebellar granule cell differentiation IEP
IEP: Inferred from expression pattern
11170002 RGD
involved in response to ionizing radiation IEP
IEP: Inferred from expression pattern
22965249 RGD
involved in response to parathyroid hormone IEP
IEP: Inferred from expression pattern
10709994 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
14766721 RGD
Cellular Component GO Annotation Evidence References Source
part of DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex IDA
IDA: Inferred from direct assay
11334111 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Top2a Protein Structure

PTZ00108

PTZ00108: PTZ00108 (23 - 1442)

DTHCT

DTHCT: pfam08070 (1432 - 1519)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1528 a.a.
Protein Preferred Names Protein Names

DNA topoisomerase 2-alpha

  • DNA topoisomerase II, alpha isozyme

  • topoisomerase (DNA) 2 alpha

  • topoisomerase (DNA) II alpha

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-111630 PluriSIn #2 Inhibitor 98.0% Unkown
HY-174374 Topobexin Inhibitor 99.04% Unkown
HY-164143 T638 Inhibitor 98.61% Unkown
HY-123393 PNU-142586 Inhibitor 97.92% Unkown
HY-RS14894 TOP2A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-175834 DNA/TOP2A-IN-1 / Unkown
HY-RS14895 Top2a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14896 Top2a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W654323 PNU-142586 sodium Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Top2a NCBI NCBI:7153