Prkdc - protein kinase, DNA-activated, catalytic subunit Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 360748

About Prkdc

Primary_assembly 11: 85,040,792-85,257,952 reverse strand.mRatBN7.2:CM026984.1

This gene has 3 transcripts (splice variants), 188 orthologues, 5 paralogues and is associated with 21 phenotypes. Biased expression in Thymus (RPKM 176.7), Spleen (RPKM 15.5) and 9 other tissues.

Summary

Predicted to enable several functions, including DNA-dependent protein kinase activity; enzyme binding activity; and nucleic acid binding activity. Involved in several processes, including hematopoietic or lymphoid organ development; negative regulation of cellular senescence; and negative regulation of response to gamma radiation. Predicted to be located in nucleolus and nucleoplasm. Predicted to be part of several cellular components, including DNA-dependent protein kinase-DNA Ligase 4 complex; protein-DNA complex; and small-subunit processome. Predicted to be active in nucleus. Used to study severe combined immunodeficiency. Human ortholog(s) of this gene implicated in immunodeficiency 26. Orthologous to human PRKDC (protein kinase, DNA-activated, catalytic subunit). [provided by Alliance of Genome Resources, Apr 2022]

Prkdc Products (1)

mRNA Protein Name
NM_001108327.2 NP_001101797.2 DNA-dependent protein kinase catalytic subunit

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in negative regulation of cellular senescence IMP
IMP: Inferred from mutant phenotype
22981234 RGD
involved in negative regulation of immunoglobulin production IMP
IMP: Inferred from mutant phenotype
22981234 RGD
involved in negative regulation of response to gamma radiation IMP
IMP: Inferred from mutant phenotype
22981234 RGD
involved in positive regulation of developmental growth IMP
IMP: Inferred from mutant phenotype
22981234 RGD
involved in positive regulation of fibroblast proliferation IMP
IMP: Inferred from mutant phenotype
22981234 RGD
involved in positive regulation of immune system process IMP
IMP: Inferred from mutant phenotype
22981234 RGD
involved in response to activity IEP
IEP: Inferred from expression pattern
21622964 RGD
involved in spleen development IMP
IMP: Inferred from mutant phenotype
22981234 RGD
involved in thymus development IMP
IMP: Inferred from mutant phenotype
22981234 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Prkdc Protein Structure

NUC194

NUC194: pfam08163 (1812 - 2195)

DNAPKcs_CC5

DNAPKcs_CC5: pfam19704 (2206 - 2888)

FAT

FAT: pfam02259 (3086 - 3470)

TEL1

TEL1: cl34875 (3456 - 4012)

PIKKc_DNA-PK

PIKKc_DNA-PK: cd05172 (3716 - 4011)

FATC

FATC: pfam02260 (4095 - 4125)

  • 0
  • 700
  • 1400
  • 2100
  • 2800
  • 3500
  • 4126 a.a.
Protein Preferred Names Protein Names

DNA-dependent protein kinase catalytic subunit

  • protein kinase, DNA activated, catalytic polypeptide

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11151 PRKDC Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11152 Prkdc Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11153 Prkdc Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Prkdc NCBI NCBI:5591