Ehmt2 - euchromatic histone lysine methyltransferase 2 Gene

Also Known as G9a; Bat8; Ng36

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 361798

About Ehmt2

Primary_assembly 20: 3,919,624-3,941,547 reverse strand.mRatBN7.2:CM026993.1

This gene has 3 transcripts (splice variants), 210 orthologues, 23 paralogues and is associated with 16 phenotypes. Biased expression in Adrenal (RPKM 211.8), Kidney (RPKM 174.5) and 9 other tissues.

Summary

Predicted to enable several functions, including C2H2 zinc finger domain binding activity; histone-lysine N-methyltransferase activity; and p53 binding activity. Involved in several processes, including long-term memory; regulation of histone methylation; and response to fungicide. Located in nucleus. Human ortholog(s) of this gene implicated in idiopathic pulmonary fibrosis. Orthologous to human EHMT2 (euchromatic histone lysine methyltransferase 2). [provided by Alliance of Genome Resources, Apr 2022]

Ehmt2 Products (1)

mRNA Protein Name
NM_212463.1 NP_997628.1 histone-lysine N-methyltransferase EHMT2

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in cellular response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
22880885 RGD
involved in long-term memory IMP
IMP: Inferred from mutant phenotype
22514307 RGD
involved in regulation of protein modification process IMP
IMP: Inferred from mutant phenotype
22514307 RGD
involved in response to alcohol IEP
IEP: Inferred from expression pattern
26509893 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
23413810 RGD
involved in response to fungicide IEP
IEP: Inferred from expression pattern
22496781 RGD
involved in response to nutrient levels IEP
IEP: Inferred from expression pattern
19001366 RGD
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
22880885 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ehmt2 Protein Structure

PHA03247

PHA03247: cl33720 (4 - 257)

EHMT_ZBD

EHMT_ZBD: cd20905 (472 - 601)

Ank_2

Ank_2: pfam12796 (716 - 803)

ANK

ANK: sd00045 (748 - 777)

Ank_2

Ank_2: pfam12796 (784 - 877)

ANK

ANK: sd00045 (812 - 844)

ANK

ANK: sd00045 (847 - 877)

Ank_2

Ank_2: pfam12796 (851 - 943)

ANK

ANK: sd00045 (879 - 910)

ANK

ANK: sd00045 (912 - 943)

SET_EHMT2

SET_EHMT2: cd10533 (1010 - 1248)

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  • 1200
  • 1273 a.a.
Protein Preferred Names Protein Names

histone-lysine N-methyltransferase EHMT2

  • HLA-B associated transcript 8, rat orthologue

  • euchromatic histone-lysine N-methyltransferase 2

  • histone-lysine N-methyltransferase, H3 lysine-9 specific 3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (14)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-16705 BRD4770 Inhibitor 99.79% Unkown
HY-111778 EHMT2-IN-1 Inhibitor 99.85% Unkown
HY-161759 MS152 Inhibitor 99.36% Unkown
HY-111904 EHMT2-IN-2 Inhibitor 99.0% Unkown
HY-183058 EZM8266 Inhibitor 98.24% Unkown
HY-15647 BRD9539 Inhibitor 99.73% Unkown
HY-44062 G9a-IN-1 Inhibitor 98.12% Unkown
HY-133031 CSV0C018875 Inhibitor / Unkown
HY-133031A CSV0C018875 hydrochloride Inhibitor / Unkown
HY-183602 FRC-303 Inhibitor / Unkown
HY-183603 FRC-222 Inhibitor / Unkown
HY-RS04230 EHMT2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04231 Ehmt2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04232 Ehmt2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ehmt2 NCBI NCBI:10919