Atl1 - atlastin GTPase 1 Gene

Also Known as Spg3a

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 362750

Summary

Enables GTP binding activity and GTPase activity. Involved in axonogenesis. Located in Golgi cis cisterna and endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in hereditary sensory neuropathy type 1D and hereditary spastic paraplegia 3A. Orthologous to human ATL1 (atlastin GTPase 1). [provided by Alliance of Genome Resources, Apr 2022]

Atl1 Products (1)

mRNA Protein Name
NM_001009831.2 NP_001009831.1 atlastin-1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables GTP binding IMP
IMP: Inferred from mutant phenotype
16537571 RGD
enables GTPase activity IDA
IDA: Inferred from direct assay
16537571 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
19665976 RGD
Biological Process GO Annotation Evidence References Source
involved in axonogenesis IMP
IMP: Inferred from mutant phenotype
16537571 RGD
Cellular Component GO Annotation Evidence References Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
14506257 RGD
located in Golgi cis cisterna IDA
IDA: Inferred from direct assay
14506257 RGD
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
16537571 RGD
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
14506257 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

atlastin-1

  • spastic paraplegia 3A homolog

Atl1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Atl1 Q6PST4 Rtn4 Rattus norvegicus Q9JK11-1
Anti Bait CoIP
19665976
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01157 ATL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01414 BCL11B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19876 Atl1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26375 Atl1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Atl1 NCBI NCBI:51062