Rangap1 - RAN GTPase activating protein 1 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 362965

Summary

Enables small GTPase binding activity and ubiquitin protein Ligase binding activity. Involved in cellular response to vasopressin and response to axon injury. Located in several cellular components, including axon cytoplasm; cytoplasmic periphery of the nuclear pore complex; and mitotic spindle. Part of nuclear pore cytoplasmic filaments. Biomarker of sciatic neuropathy. Orthologous to human RANGAP1 (Ran GTPase activating protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Rangap1 Products (1)

mRNA Protein Name
NM_001244855.1 NP_001231784.1 ran GTPase-activating protein 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
9019411 RGD
enables small GTPase binding IDA
IDA: Inferred from direct assay
8978815 RGD
enables ubiquitin protein ligase binding IPI
IPI: Inferred from physical interaction
9497385 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to peptide hormone stimulus IDA
IDA: Inferred from direct assay
22811487 RGD
involved in cellular response to vasopressin IEP
IEP: Inferred from expression pattern
22811487 RGD
involved in response to axon injury IEP
IEP: Inferred from expression pattern
18667152 RGD
Cellular Component GO Annotation Evidence References Source
located in axon cytoplasm IDA
IDA: Inferred from direct assay
18667152 RGD
located in cytoplasmic periphery of the nuclear pore complex IDA
IDA: Inferred from direct assay
9019411 RGD
located in dendrite IDA
IDA: Inferred from direct assay
18667152 RGD
located in mitotic spindle IDA
IDA: Inferred from direct assay
8978815 RGD
part of nuclear pore IDA
IDA: Inferred from direct assay
22811487 RGD
part of nuclear pore cytoplasmic filaments IDA
IDA: Inferred from direct assay
8978815 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ran GTPase-activating protein 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11650 RANGAP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-123888 Viomellein Inhibitor / Unkown
HY-181772 MCULE-3064932370 Inhibitor / Unkown
HY-RS22022 Rangap1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28540 Rangap1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rangap1 NCBI NCBI:5905