Ncf2 - neutrophil cytosolic factor 2 Gene

Also Known as NCF-2

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 364018

Summary

Predicted to enable protein C-terminus binding activity; small GTPase binding activity; and superoxide-generating NADPH Oxidase activator activity. Predicted to contribute to superoxide-generating NAD(P)H oxidase activity. Involved in several processes, including response to hyperoxia; response to laminar fluid shear stress; and response to progesterone. Located in cytoplasm and membrane. Used to study proteinuria; renal fibrosis; and visual epilepsy. Biomarker of hypertension and obesity. Human ortholog(s) of this gene implicated in Alzheimer's disease; autosomal recessive chronic granulomatous disease cytochrome b-positive type II; and rheumatoid arthritis. Orthologous to human NCF2 (neutrophil cytosolic factor 2). [provided by Alliance of Genome Resources, Apr 2022]

Ncf2 Products (1)

mRNA Protein Name
NM_001395185.1 NP_001382114.1 neutrophil cytosol factor 2

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in cellular response to hormone stimulus IDA
IDA: Inferred from direct assay
18298462 RGD
involved in positive regulation of blood pressure IMP
IMP: Inferred from mutant phenotype
19307699 RGD
involved in positive regulation of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
18675340 RGD
involved in regulation of reactive oxygen species biosynthetic process IMP
IMP: Inferred from mutant phenotype
27279484 RGD
involved in response to activity IEP
IEP: Inferred from expression pattern
17310390 RGD
involved in response to glucose IDA
IDA: Inferred from direct assay
19854265 RGD
involved in response to hyperoxia IEP
IEP: Inferred from expression pattern
19337906 RGD
involved in response to laminar fluid shear stress IEP
IEP: Inferred from expression pattern
19353375 RGD
involved in response to lipid IEP
IEP: Inferred from expression pattern
19713964 RGD
involved in response to lipopolysaccharide IDA
IDA: Inferred from direct assay
17448908 RGD
involved in response to organic cyclic compound IDA
IDA: Inferred from direct assay
19854265 RGD
involved in response to progesterone IEP
IEP: Inferred from expression pattern
19841131 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
17122189 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

neutrophil cytosol factor 2

  • neutrophil NADPH oxidase factor 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09078 NCF2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19358 Ncf2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25849 Ncf2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ncf2 NCBI NCBI:4688