Slc22a12 - solute carrier family 22 member 12 Gene

Also Known as Rst; URAT1; Slc22al2

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 365398

About Slc22a12

Primary_assembly 1: 203,845,048-203,853,555 reverse strand.mRatBN7.2:CM026974.1

This gene has 3 transcripts (splice variants), 475 orthologues, 24 paralogues and is associated with 8 phenotypes. Restricted expression toward (RPKM 74.6).

Summary

Predicted to enable PDZ domain binding activity and urate transmembrane transporter activity. Involved in cellular response to Insulin stimulus; urate salt excretion; and urate transport. Located in apical plasma membrane. Biomarker of diabetes mellitus. Orthologous to human SLC22A12 (solute carrier family 22 member 12). [provided by Alliance of Genome Resources, Apr 2022]

Slc22a12 Products (1)

mRNA Protein Name
NM_001034943.1 NP_001030115.1 solute carrier family 22 member 12

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in cellular response to insulin stimulus IEP
IEP: Inferred from expression pattern
28679589 RGD
involved in renal urate salt excretion IEP
IEP: Inferred from expression pattern
28679589 RGD
involved in urate transport IDA
IDA: Inferred from direct assay
21074513 RGD
Cellular Component GO Annotation Evidence References Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
21074513 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Slc22a12 Protein Structure

MFS_OAT

MFS_OAT: cd17374 (108 - 540)

  • 0
  • 100
  • 200
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  • 400
  • 500
  • 578 a.a.
Protein Preferred Names Protein Names

solute carrier family 22 member 12

  • solute carrier family 22 (organic anion/cation transporter), member 12

  • solute carrier family 22 (organic anion/urate transporter), member 12

  • solute carrier family 22 (organic cation transporter)-like 2

  • urate anion exchanger 1

  • urate:anion antiporter SLC22A12

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-173231 hURAT1 inhibitor 2 Inhibitor / Unkown
HY-RS13063 SLC22A12 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13064 Slc22a12 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13065 Slc22a12 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Slc22a12 NCBI NCBI:116085