SP3 - Sp3 Sp3 transcription factor Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 367846

Summary

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II-specific DNA-binding transcription factor binding activity; and transcription cis-regulatory region binding activity. Involved in negative regulation of transcription, DNA-templated. Located in nucleus. Part of protein-DNA complex and transcription repressor complex. Orthologous to human SP3 (Sp3 transcription factor). [provided by Alliance of Genome Resources, Apr 2022]

SP3 Products (3)

mRNA Protein Name
XM_039106378.1 XP_038962306.1 transcription factor Sp3 isoform X2
XM_039106376.1 XP_038962304.1 transcription factor Sp3 isoform X1
XM_039106379.1 XP_038962307.1 transcription factor Sp3 isoform X3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
17130167 RGD
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IGI
IGI: Inferred from genetic interaction
10362258 RGD
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IMP
IMP: Inferred from mutant phenotype
14979875 RGD
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
IPI: Inferred from physical interaction
17130167 RGD
Biological Process GO Annotation Evidence References Source
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
17130167 RGD
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
14979875 RGD
part of protein-DNA complex IPI
IPI: Inferred from physical interaction
10362258 RGD
part of transcription repressor complex IDA
IDA: Inferred from direct assay
17130167 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

transcription factor Sp3

  • trans-acting transcription factor 3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-161794A SP3N hydrochloride Degrader 99.84% Unkown
HY-161795 SP3CHO 87.50% Unkown
HY-161794 SP3N Degrader / Unkown
HY-RS13606 SP3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-123732 CRT0083914 / Unkown
HY-173132 AKR1Cs-IN-1 / Unkown
HY-180813 RORγ-IN-3 Inhibitor / Unkown
HY-RS18594 Sp3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25079 Sp3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens SP3 NCBI NCBI:6670