Rc3h1 - RING CCCH (C3H) domains 1 Gene

Also Known as Gm551; mKIAA2025; 5730557L09Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 381305

Summary

Enables RNA binding activity and zinc ion binding activity. Involved in several processes, including P-body assembly; negative regulation of lymphocyte activation; and regulation of RNA metabolic process. Acts upstream of or within several processes, including hematopoietic or lymphoid organ development; lymphocyte homeostasis; and positive regulation of NIK/NF-kappaB signaling. Located in P-body and cytoplasmic stress granule. Used to study peripheral T-cell lymphoma and systemic lupus erythematosus. Orthologous to human RC3H1 (ring finger and CCCH-type domains 1). [provided by Alliance of Genome Resources, Apr 2022]

Rc3h1 Products (1)

mRNA Protein Name
NM_001024952.2 NP_001020123.1 roquin-1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables RNA stem-loop binding IDA
IDA: Inferred from direct assay
25026077 MGI
enables mRNA 3'-UTR binding IDA
IDA: Inferred from direct assay
20639877 MGI
enables mRNA binding IDA
IDA: Inferred from direct assay
23583643 MGI
enables miRNA binding IDA
IDA: Inferred from direct assay
25697406 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
20639877 MGI
enables zinc ion binding IDA
IDA: Inferred from direct assay
25697406 MGI
Biological Process GO Annotation Evidence References Source
involved in 3'-UTR-mediated mRNA destabilization IDA
IDA: Inferred from direct assay
26000482 MGI
acts upstream of or within B cell homeostasis IGI
IGI: Inferred from genetic interaction
23583643 MGI
involved in P-body assembly IMP
IMP: Inferred from mutant phenotype
20639877 MGI
acts upstream of or within T cell homeostasis IGI
IGI: Inferred from genetic interaction
23583643 MGI
acts upstream of or within T cell proliferation IGI
IGI: Inferred from genetic interaction
23583643 MGI
involved in T cell receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
25282160 MGI
acts upstream of or within T follicular helper cell differentiation IGI
IGI: Inferred from genetic interaction
23583643 MGI
acts upstream of or within lymph node development IGI
IGI: Inferred from genetic interaction
23583643 MGI
involved in negative regulation of B cell proliferation IMP
IMP: Inferred from mutant phenotype
18172933 MGI
involved in negative regulation of T-helper 17 cell differentiation IMP
IMP: Inferred from mutant phenotype
25282160 MGI
acts upstream of or within negative regulation of T-helper cell differentiation IMP
IMP: Inferred from mutant phenotype
15917799 MGI
involved in negative regulation of activated T cell proliferation IMP
IMP: Inferred from mutant phenotype
18172933 MGI
involved in negative regulation of germinal center formation IMP
IMP: Inferred from mutant phenotype
18172933 MGI
involved in nuclear-transcribed mRNA catabolic process IMP
IMP: Inferred from mutant phenotype
20639877 MGI
involved in nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IMP
IMP: Inferred from mutant phenotype
26000482 MGI
involved in positive regulation of mRNA catabolic process IDA
IDA: Inferred from direct assay
26000482 MGI
involved in positive regulation of mRNA catabolic process IMP
IMP: Inferred from mutant phenotype
25026077 MGI
acts upstream of or within positive regulation of non-canonical NF-kappaB signal transduction IDA
IDA: Inferred from direct assay
23583643 MGI
acts upstream of or within post-transcriptional regulation of gene expression IDA
IDA: Inferred from direct assay
23583643 MGI
involved in post-transcriptional regulation of gene expression IMP
IMP: Inferred from mutant phenotype
20639877 MGI
involved in regulation of T cell receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
15917799 MGI
acts upstream of or within regulation of gene expression IDA
IDA: Inferred from direct assay
23583643 MGI
involved in regulation of germinal center formation IMP
IMP: Inferred from mutant phenotype
15917799 MGI
involved in regulation of mRNA stability IMP
IMP: Inferred from mutant phenotype
18172933 MGI
involved in regulation of miRNA metabolic process IMP
IMP: Inferred from mutant phenotype
25697406 MGI
acts upstream of or within spleen development IGI
IGI: Inferred from genetic interaction
23583643 MGI
Cellular Component GO Annotation Evidence References Source
located in P-body IDA
IDA: Inferred from direct assay
20639877 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
15917799 MGI
located in cytoplasmic stress granule IDA
IDA: Inferred from direct assay
15917799 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

roquin-1

  • RING finger and C3H zinc finger protein 1

  • RING finger and CCCH-type zinc finger domain-containing protein 1

  • probable E3 ubiquitin-protein ligase Roquin

  • protein Sanroque

  • roquin

Rc3h1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Rc3h1 Q4VGL6 Edc4 Mus musculus Q3UJB9
Anti Bait CoIP
20639877
Intra
Rc3h1 Q4VGL6 Ago2 Mus musculus Q8CJG0
Anti Bait CoIP
25697406
Intra
Rc3h1 Q4VGL6 Ago2 Mus musculus Q8CJG0
Anti Tag CoIP
25697406
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11777 RC3H1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rc3h1 NCBI NCBI:149041