Crtc1 - CREB regulated transcription coactivator 1 Gene

Also Known as Mect1; TORC1; TORC-1; mKIAA0616

Species: Mus musculus

Gene Type: protein coding
Gene ID: 382056

Summary

Predicted to enable cAMP response element binding protein binding activity. Involved in entrainment of circadian clock by photoperiod and positive regulation of CREB transcription factor activity. Acts upstream of or within several processes, including energy homeostasis; memory; and negative regulation of membrane hyperpolarization. Located in cytoplasm and nucleus. Is expressed in limb and limb mesenchyme. Used to study major depressive disorder. Orthologous to human CRTC1 (CREB regulated transcription coactivator 1). [provided by Alliance of Genome Resources, Apr 2022]

Crtc1 Products (17)

mRNA Protein Name
NM_001004062.3 NP_001004062.1 CREB-regulated transcription coactivator 1 isoform 2
NM_001404415.1 NP_001391344.1 CREB-regulated transcription coactivator 1 isoform 1
NM_001404416.1 NP_001391345.1 CREB-regulated transcription coactivator 1 isoform 3
NM_001404417.1 NP_001391346.1 CREB-regulated transcription coactivator 1 isoform 4
NM_001404418.1 NP_001391347.1 CREB-regulated transcription coactivator 1 isoform 5
NM_001404419.1 NP_001391348.1 CREB-regulated transcription coactivator 1 isoform 6
NM_001404420.1 NP_001391349.1 CREB-regulated transcription coactivator 1 isoform 7
NM_001404421.1 NP_001391350.1 CREB-regulated transcription coactivator 1 isoform 8
NM_001404422.1 NP_001391351.1 CREB-regulated transcription coactivator 1 isoform 9
NM_001404423.1 NP_001391352.1 CREB-regulated transcription coactivator 1 isoform 10
NM_001404424.1 NP_001391353.1 CREB-regulated transcription coactivator 1 isoform 11
NM_001404425.1 NP_001391354.1 CREB-regulated transcription coactivator 1 isoform 12
NM_001404426.1 NP_001391355.1 CREB-regulated transcription coactivator 1 isoform 13
NM_001404427.1 NP_001391356.1 CREB-regulated transcription coactivator 1 isoform 14
NM_001404428.1 NP_001391357.1 CREB-regulated transcription coactivator 1 isoform 15
NM_001404429.1 NP_001391358.1 CREB-regulated transcription coactivator 1 isoform 16
NM_001404430.1 NP_001391359.1 CREB-regulated transcription coactivator 1 isoform 16

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
30611118 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within energy homeostasis IMP
IMP: Inferred from mutant phenotype
19734865 MGI
involved in entrainment of circadian clock by photoperiod IMP
IMP: Inferred from mutant phenotype
23993098 MGI
acts upstream of or within memory IMP
IMP: Inferred from mutant phenotype
23223304 MGI
acts upstream of or within metabolic process IMP
IMP: Inferred from mutant phenotype
19734865 MGI
acts upstream of or within negative regulation of membrane hyperpolarization IDA
IDA: Inferred from direct assay
23223304 MGI
involved in positive regulation of CREB transcription factor activity IMP
IMP: Inferred from mutant phenotype
23993098 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
23223304 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
23223304 MGI
located in nucleus IDA
IDA: Inferred from direct assay
23223304 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

CREB-regulated transcription coactivator 1

  • mucoepidermoid carcinoma translocated 1

  • mucoepidermoid carcinoma translocated protein 1 homolog

  • transducer of CREB protein 1

  • transducer of regulated cAMP response element-binding protein 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (13)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N0059 D-Arabinose ≥99.0% Unkown
HY-N7082 D-Arabinopyranose 99.94% Unkown
HY-N0059R D-Arabinose (Standard) / Unkown
HY-N0059S D-Arabinose-13C / Unkown
HY-N0059S1 D-Arabinose-13C-1 / Unkown
HY-N0059S2 D-arabinose-13C-2 / Unkown
HY-N0059S3 D-Arabinose-13C-3 / Unkown
HY-N0059S4 D-Arabinose-d2 / Unkown
HY-N0059S5 D-Arabinose-d5 / Unkown
HY-N0059S6 D-Arabinose-d6 / Unkown
HY-N7082S D-Arabinopyranose-13C5 99.9% Unkown
HY-RS03200 CRTC1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22459 Crtc1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Crtc1 NCBI NCBI:23373