CRTC1 - CREB regulated transcription coactivator 1 Gene

Also Known as MAML2; MECT1; Mam-2; TORC1; TORC-1; WAMTP1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23373

About CRTC1

Cytogenetic location: 19p13.11 Genomic coordinates (GRCh38): 19:18,683,680-18,782,333 (from NCBI)

This gene has 4 transcripts (splice variants), 260 orthologues, 2 paralogues and is associated with 82 phenotypes. Ubiquitous expression in brain (RPKM 4.7), testis (RPKM 2.0) and 24 other tissues.

Summary

Enables cAMP response element binding protein binding activity. Involved in positive regulation of transcription by RNA polymerase II. Located in cytosol; nuclear body; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

CRTC1 Products (2)

mRNA Protein Name
NM_001098482.2 NP_001091952.1 CREB-regulated transcription coactivator 1 isoform 3
NM_015321.3 NP_056136.2 CREB-regulated transcription coactivator 1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cAMP response element binding protein binding IDA
IDA: Inferred from direct assay
14536081 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
14506290 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
14536081 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
14506290 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CRTC1 Protein Structure

TORC_N

TORC_N: Transducer of regulated CREB activity, N terminus (6 - 66)

TORC_M

TORC_M: Transducer of regulated CREB activity middle domain (148 - 294)

TORC_C

TORC_C: Transducer of regulated CREB activity, C terminus (559 - 634)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 600
  • 634 a.a.
Protein Preferred Names Protein Names

CREB-regulated transcription coactivator 1

  • Mastermind-like protein 2

CRTC1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CRTC1 Q6UUV9 YWHAE Homo sapiens P62258
Crosslink
36931259
Cross: Cross-species interaction Intra: Intraspecies interaction

CRTC1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P81325 TORC1 Antibody (YA1070) WB, ICC/IF, IP, FC Human
HY-P81325A TORC1 Antibody (YA1070)(PBS only) WB, ICC/IF, IP, FC Human
HY-P85478 TORC1 Antibody (YA5170) WB, FC, ICC/IF Human, Mouse, Rat, Pig

Related Diseases

Diseases Alias
Mucoepidermoid Carcinoma

  • Mec

  • Salivary Gland Mucoepidermoid Carcinoma

  • C3772

  • Carcinoma Mucoepidermoid

  • Carcinoma, Mucoepidermoid
Salivary Gland Carcinoma

  • Salivary Gland Cancer

  • Malignant Neoplasm Of Salivary Gland

  • Salivary Gland Neoplasms
Human T-Cell Leukemia Virus Type 1

  • Htlv-1

  • Human T Lymphotropic Virus Type 1
Lacrimal Gland Mucoepidermoid Carcinoma

  • Mucoepidermoid Carcinoma Of The Lacrimal Gland
Cutaneous Mucoepidermoid Carcinoma

  • Mucoepidermoid Carcinoma Of Skin

  • Mucoepidermoid Skin Carcinoma
Bronchus Mucoepidermoid Carcinoma
Clear Cell Hidradenoma

  • Clear Cell Myoepithelioma

  • Eccrine Acrospiroma
Breast Mucoepidermoid Carcinoma

  • Mucoepidermoid Carcinoma Of Breast

  • Mucoepidermoid Carcinoma Of The Breast
Salivary Gland Disease

  • Salivary Gland Disorders

  • Salivary Gland Diseases

  • Non-Neoplastic Salivary Gland Disease

  • Non-Neoplastic Salivary Gland Disorder

  • Disorder Of Salivary Gland

  • Lesion Of Salivary Gland Nos
Pleomorphic Adenoma Carcinoma

  • Carcinoma Ex Pleomorphic Adenoma

  • Carcinoma In Pleomorphic Adenoma
Cervical Adenosquamous Carcinoma

  • Adenosquamous Carcinoma Of Cervix

  • Adenosquamous Cell Carcinoma Of The Cervix Uteri
Lipoadenoma
Hidradenoma

  • Adenoma, Sweat Gland

  • Hidradenoma Of Skin

  • Sweat Gland Adenoma

  • Syringoadenoma

  • Eccrine Acrospiroma

  • Benign Neoplasm Of Sweat Gland
Necrotizing Sialometaplasia

  • Sialometaplasia, Necrotizing
Epithelial-Myoepithelial Carcinoma

  • Clear Cell Adenoma

  • Adenomyo-Epithelioma

  • Clear Cell Carcinoma

  • Emc

  • Epithelial Myoepithelial Carcinoma

  • Glycogen-Rich Adenocarcinoma

  • Glycogen-Rich Adenoma

  • Monomorphic Clear Cell Tumor

  • Tubular Solid Adenoma

  • Adenocarcinoma, Clear Cell
Mammary Analogue Secretory Carcinoma
Endobronchial Lipoma
Tonsil Cancer

  • Tonsillar Neoplasms

  • Malignant Neoplasm Of Faucial Tonsil

  • Malignant Neoplasm Of Palatine Tonsil

  • Malignant Neoplasm Of Tonsil, Faucial

  • Malignant Tonsillar Tumor

  • Malignant Tumor Of Tonsil

  • Tonsillar Carcinoma

  • Malignant Neoplasm Tonsil
Schneiderian Carcinoma

  • Cylindrical Cell Carcinoma
Bile Duct Mucoepidermoid Carcinoma

  • Mucoepidermoid Carcinoma Of The Bile Duct

  • Extrahepatic Bile Duct Mucoepidermoid Carcinoma
Breast Metaplastic Carcinoma

  • Metaplastic Carcinoma Of The Breast

  • Metaplastic Breast Carcinoma

  • Metaplastic Carcinoma Of Breast

  • Metaplastic Breast Cancer
Sweat Gland Benign Neoplasm

  • Neoplasm Of Sweat Gland

  • Sweat Gland Tumor

  • Tumor Of The Sweat Gland

  • Sweat Gland Neoplasms

  • Sweat Gland Neoplasm
Esophageal Adenoid Cystic Carcinoma

  • Adenoid Cystic Carcinoma, Esophagus
Eccrine Acrospiroma

  • Acrospiroma

  • Poroma

  • Eccrine Hidradenoma

  • Eccrine Hidradenoma Of Skin

  • Hidradenoma

  • Adenoma, Sweat Gland

  • Benign Neoplasm Of Sweat Gland

  • Eccrine Poroma
Lung Adenoid Cystic Carcinoma

  • Adenoid Cystic Carcinoma Of Lung

  • Pulmonary Adenoid Cystic Carcinoma
Oropharynx Cancer

  • Oropharyngeal Cancer

  • Oropharyngeal Carcinoma

  • Malignant Neoplasm Of Oropharynx

  • Malignant Oropharyngeal Tumor

  • Malignant Tumor Of Oropharynx

  • Malignant Tumour Of Mesopharynx

  • Oropharyngeal Cancer, Adult

  • Cancer Of The Oropharynx
Eccrine Sweat Gland Neoplasm

  • Eccrine Skin Neoplasm

  • Eccrine Tumor

  • Eccrine Neoplasm

  • Malignant Eccrine Neoplasm
Pancreatic Adenosquamous Carcinoma

  • Adenosquamous Carcinoma Of Pancreas

  • Adenosquamous Carcinoma Of The Pancreas
Myoepithelial Carcinoma

  • Malignant Myoepithelioma

  • Myoepithelioma Carcinoma
Acinar Cell Carcinoma

  • Acinic Cell Carcinoma

  • Acinic Cell Tumor

  • Carcinoma Acinar Cell

  • Carcinoma, Acinar Cell

  • Acinar Cell Tumor
Lacrimal System Cancer

  • Neoplasm Of Lacrimal System

  • Lacrimal System Neoplasm

  • Tumor Of The Lacrimal System
Papillary Cystadenocarcinoma

  • Cystadenocarcinoma, Papillary
Sweat Gland Disease

  • Sweat Gland Diseases
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (13)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N0059 D-Arabinose ≥99.0% Unkown
HY-N7082 D-Arabinopyranose 99.94% Unkown
HY-N0059R D-Arabinose (Standard) / Unkown
HY-N0059S D-Arabinose-13C / Unkown
HY-N0059S1 D-Arabinose-13C-1 / Unkown
HY-N0059S2 D-arabinose-13C-2 / Unkown
HY-N0059S3 D-Arabinose-13C-3 / Unkown
HY-N0059S4 D-Arabinose-d2 / Unkown
HY-N0059S5 D-Arabinose-d5 / Unkown
HY-N0059S6 D-Arabinose-d6 / Unkown
HY-N7082S D-Arabinopyranose-13C5 99.9% Unkown
HY-RS03200 CRTC1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22459 Crtc1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris CRTC1 VGNC VGNC:103667
Rattus norvegicus CRTC1 RGD RGD:1589158
Macaca mulatta CRTC1 VGNC VGNC:71418
Mus musculus CRTC1 MGD MGI:2142523
Felis catus CRTC1 VGNC VGNC:61192
Bos taurus CRTC1 VGNC VGNC:27728
Others CRTC1 NCBI