SKOR1 - SKI family transcriptional corepressor 1 Gene

Also Known as CORL1; LBXCOR1; FUSSEL15

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 390598

About SKOR1

Cytogenetic location: 15q23 Genomic coordinates (GRCh38): 15:67,825,509-67,834,582 (from NCBI)

This gene has 4 transcripts (splice variants), 246 orthologues and 3 paralogues. Low expression observed in reference dataset.

Summary

Enables SMAD binding activity and sequence-specific double-stranded DNA binding activity. Involved in negative regulation of BMP signaling pathway. Located in dendrite and neuronal cell body. [provided by Alliance of Genome Resources, Apr 2022]

SKOR1 Products (1)

mRNA	Protein	Name
NM_001365915.1	NP_001352844.1	SKI family transcriptional corepressor 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables SMAD binding	IPI IPI: Inferred from physical interaction	17292623	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of BMP signaling pathway	IDA IDA: Inferred from direct assay	17292623	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in dendrite	IDA IDA: Inferred from direct assay	17292623	GOA
located in neuronal cell body	IDA IDA: Inferred from direct assay	17292623	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SKOR1 Protein Structure

Ski_Sno

c-SKI_SMAD_bind

0
200
400
600
800
965 a.a.

Protein Preferred Names	Protein Names
SKI family transcriptional corepressor 1	LBX1 corepressor 1

Related Diseases

Diseases	Alias
Restless Legs Syndrome	Wed Willis-Ekbom Disease Restless Leg Syndrome Ekbom Syndrome Wittmaack-Ekbom Syndrome Willis Ekbom Disease Ekbom'S Syndrome Rls Restless Legs Restless Legs Syndrome, Susceptibility To
Periodic Limb Movement Disorder	Nocturnal Myoclonus Syndrome Nocturnal Myoclonus
Osgood-Schlatter'S Disease	Osgood-Schlatter Disease Juvenile Osteochondrosis Of Tibial Tubercle Osteochondrosis Osteochondritis Of Tibial Tubercle Osteochondrosis Of Proximal Tibia Aseptic Necrosis Of The Tibial Tubercle Osteochondrosis Of The Tibial Tubercle Osteochondritis Juvenilis
Essential Tremor	Benign Essential Tremor Familial Tremor Hereditary Essential Tremor Essential Hereditary Tremor Shaky Hand Syndrome Benign Essential Tremor Syndrome Tremor Hereditary Essential Essential Tremor, Susceptibility To Tremor, Hereditary Essential
Pulmonary Subvalvular Stenosis	Pulmonary Infundibular Stenosis Congenital Infundibular Stenosis Infundibular Pulmonic Stenosis Infundibular Pulmonic Stenosis, Congenital Subvalvular Pulmonic Stenosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12971	SKOR1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	SKOR1	VGNC	VGNC:55143
Rattus norvegicus	SKOR1	RGD	RGD:1307687
Felis catus	SKOR1	VGNC	VGNC:104718
Mus musculus	SKOR1	MGD	MGI:2443473
Macaca mulatta	SKOR1	VGNC	VGNC:77544
Others	SKOR1	NCBI