Gjb2 - gap junction protein, beta 2 Gene

Also Known as Cx26; Cxne; CXN-26

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 394266

Summary

Enables gap junction channel activity. Involved in several processes, including cellular response to glucagon stimulus; reproductive structure development; and response to steroid hormone. Located in several cellular components, including astrocyte projection; gap junction; and lateral plasma membrane. Used to study hepatocellular carcinoma and lung adenocarcinoma. Biomarker of autoimmune thyroiditis; extrahepatic cholestasis; ischemia; sensorineural hearing loss; and urethral obstruction. Human ortholog(s) of this gene implicated in Bart-Pumphrey syndrome; Vohwinkel syndrome; autosomal dominant keratitis-ichthyosis-deafness syndrome; nonsyndromic deafness (multiple); and palmoplantar keratoderma-deafness syndrome. Orthologous to human GJB2 (Gap Junction Protein beta 2). [provided by Alliance of Genome Resources, Apr 2022]

Gjb2 Products (1)

mRNA	Protein	Name
NM_001004099.2	NP_001004099.1	gap junction beta-2 protein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables gap junction channel activity	IMP IMP: Inferred from mutant phenotype	23232329	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	19864490	RGD

Biological Process GO Annotation	Evidence	Références	Source
involved in cellular response to dexamethasone stimulus	IEP IEP: Inferred from expression pattern	7593318	RGD
involved in cellular response to glucagon stimulus	IEP IEP: Inferred from expression pattern	7593318	RGD
involved in cellular response to oxidative stress	IEP IEP: Inferred from expression pattern	8631141	RGD
involved in decidualization	IEP IEP: Inferred from expression pattern	1655436	RGD
involved in epididymis development	IEP IEP: Inferred from expression pattern	12388089	RGD
involved in female pregnancy	IEP IEP: Inferred from expression pattern	8612484	RGD
involved in inner ear development	IEP IEP: Inferred from expression pattern	10570462	RGD
involved in response to estradiol	IEP IEP: Inferred from expression pattern	10342836	RGD
involved in response to human chorionic gonadotropin	IEP IEP: Inferred from expression pattern	9537254	RGD
involved in response to ischemia	IEP IEP: Inferred from expression pattern	24728265	RGD
involved in response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	10909894	RGD
involved in response to progesterone	IEP IEP: Inferred from expression pattern	8612484	RGD
involved in response to retinoic acid	IEP IEP: Inferred from expression pattern	9570757	RGD

Cellular Component GO Annotation	Evidence	Références	Source
located in astrocyte projection	IDA IDA: Inferred from direct assay	11169992	RGD
located in cell body	IDA IDA: Inferred from direct assay	11169992	RGD
located in cell junction	IDA IDA: Inferred from direct assay	8770903	RGD
located in gap junction	IDA IDA: Inferred from direct assay	12064610	RGD
located in lateral plasma membrane	IDA IDA: Inferred from direct assay	12388089	RGD
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	11738649	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
gap junction beta-2 protein	connexin 26 connexin e gap junction channel protein connexin 26 gap junction membrane channel protein beta 2

Gjb2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Cross	Gjb2	P21994	Cnst	Mus musculus	Q8CBC4-3	Pull Down	19864490

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-RS05447	GJB2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20742	Gjb2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27254	Gjb2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gjb2	NCBI	NCBI:2706