C4b - complement C4B (Chido blood group) Gene

Also Known as C4l; C4-2

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 406161

Summary

Predicted to enable carbohydrate binding activity and complement component C1q complex binding activity. Predicted to be involved in complement activation; detection of molecule of Bacterial origin; and positive regulation of apoptotic cell clearance. Predicted to act upstream of or within immunoglobulin mediated immune response. Located in extracellular space. Human ortholog(s) of this gene implicated in autistic disorder; autoimmune disease (multiple); complement component 4b deficiency; and renal cell carcinoma. Orthologous to human C4B (complement C4B (Chido blood group)). [provided by Alliance of Genome Resources, Apr 2022]

C4b Products (1)

mRNA Protein Name
NM_001002805.2 NP_001002805.1 complement component 4, gene 2 precursor

Gene Ontology

  • Cellular Component
Cellular Component GO Annotation Evidence References Source
located in extracellular region IDA
IDA: Inferred from direct assay
8805663 RGD
located in extracellular space IDA
IDA: Inferred from direct assay
15634920 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

complement component 4, gene 2

  • complement C4-like protein

  • complement component 4B (Chido blood group)

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Phase
HY-P990091 Riliprubart Inhibitor 99.90% Phase 3
HY-P99905 Efdamrofusp alfa 99.89% Phase 3

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS18586 C4b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01746 C4B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18215 C4a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24692 C4a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25071 C4b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens C4b NCBI NCBI:721