ASGR2 - asialoglycoprotein receptor 2 Gene
Also Known as HL-2; HBXBP; ASGPR2; ASGP-R2; CLEC4H2
Species: Homo sapiens
About ASGR2
This gene has 7 transcripts (splice variants), 141 orthologues and 14 paralogues. Biased expression in liver (RPKM 120.6) and gall bladder (RPKM 6.7).
Summary
This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic Infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the less abundant minor subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]
ASGR2 Products (5)
| mRNA | Protein | Name |
|---|---|---|
| NM_001181.4 | NP_001172.1 | asialoglycoprotein receptor 2 isoform a |
| NM_001201352.2 | NP_001188281.1 | asialoglycoprotein receptor 2 isoform d |
| NM_080912.3 | NP_550434.1 | asialoglycoprotein receptor 2 isoform a |
| NM_080913.3 | NP_550435.1 | asialoglycoprotein receptor 2 isoform b |
| NM_080914.2 | NP_550436.1 | asialoglycoprotein receptor 2 isoform c |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
11408579 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in endoplasmic reticulum quality control compartment |
IDA
IDA: Inferred from direct assay
|
11408579 | GOA |
| located in perinuclear region of cytoplasm |
IDA
IDA: Inferred from direct assay
|
11408579 | GOA |
ASGR2 Protein Structure
Lectin_N: Hepatic lectin, N-terminal domain (27 - 167)
Lectin_C: Lectin C-type domain (195 - 302)
- 0
- 100
- 200
- 311 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
asialoglycoprotein receptor 2 |
|
Recombinant ASGR2 Proteins
| Cat. No. | Product Name | Accession | Purity |
|---|---|---|---|
| HY-P76736 | ASGR2/ASGPR2 Protein, Human (HEK293, His) | P07307 (Q80-A311) | ≥ 90%, as determined by reducing SDS-PAGE. |
ASGR2 Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P83987 | ASGR2 Antibody (YA3684) | IHC-P, FC, ELISA | Human |
| HY-P83987A | ASGR2 Antibody (YA3684)(PBS only) | IHC-P, FC, ELISA | Human |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Hepatitis |
|
|
| Hepatitis B |
|
|
| Autoimmune Hepatitis |
|
|
| Liver Cirrhosis |
|
|
Related Agents
- Pre-clinical Phase
Pre-clinical Phase
| Cat. No. | Product Name |
Effect
|
Purity |
Rare Diseases
|
|---|---|---|---|---|
| HY-RS01086 | ASGR2 Human Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
| HY-RS19410 | Asgr2 Mouse Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
| HY-RS25902 | Asgr2 Rat Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Canis familiaris | ASGR2 | VGNC | VGNC:53264 |
| Rattus norvegicus | ASGR2 | RGD | RGD:2161 |
| Bos taurus | ASGR2 | VGNC | VGNC:55035 |
| Macaca mulatta | ASGR2 | VGNC | VGNC:99121 |
| Mus musculus | ASGR2 | MGD | MGI:88082 |
| Others | ASGR2 | NCBI |
Compound Screening Libraries
Virtual Screening
Customize Your Library
Drug Screening Service