Trim72 - tripartite motif-containing 72 Gene

Also Known as MG53

Species: Mus musculus

Gene Type: protein coding

Gene ID: 434246

Summary

Enables phosphatidylserine binding activity; ubiquitin conjugating enzyme binding activity; and ubiquitin protein Ligase activity. Involved in several processes, including muscle organ development; plasma membrane repair; and protein homooligomerization. Acts upstream of or within negative regulation of myotube differentiation; negative regulation of signal transduction; and proteasome-mediated ubiquitin-dependent protein catabolic process. Located in cytoplasmic vesicle membrane and sarcolemma. Is expressed in heart; heart left ventricle; heart right ventricle; left atrium; and right atrium. Orthologous to human TRIM72 (tripartite motif containing 72). [provided by Alliance of Genome Resources, Apr 2022]

Trim72 Products (1)

mRNA	Protein	Name
NM_001079932.3	NP_001073401.1	tripartite motif-containing protein 72

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables phosphatidylserine binding	IDA IDA: Inferred from direct assay	19043407	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	19380584	MGI
enables ubiquitin conjugating enzyme binding	IDA IDA: Inferred from direct assay	23965929	MGI
enables ubiquitin protein ligase activity	IMP IMP: Inferred from mutant phenotype	23965929	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in muscle organ development	IMP IMP: Inferred from mutant phenotype	19043407	MGI
involved in muscle system process	IMP IMP: Inferred from mutant phenotype	19043407	MGI
acts upstream of or within negative regulation of insulin receptor signaling pathway	IDA IDA: Inferred from direct assay	23965929	MGI
acts upstream of or within negative regulation of insulin-like growth factor receptor signaling pathway	IGI IGI: Inferred from genetic interaction	23965929	MGI
acts upstream of or within negative regulation of myotube differentiation	IDA IDA: Inferred from direct assay	23965929	MGI
acts upstream of or within plasma membrane repair	IMP IMP: Inferred from mutant phenotype	19380584	MGI
involved in plasma membrane repair	IMP IMP: Inferred from mutant phenotype	19043407	MGI
acts upstream of or within proteasome-mediated ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	23965929	MGI
involved in protein homooligomerization	IPI IPI: Inferred from physical interaction	19043407	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasmic vesicle membrane	IDA IDA: Inferred from direct assay	19029292	MGI
located in sarcolemma	IDA IDA: Inferred from direct assay	19029292	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
tripartite motif-containing protein 72	mitsugumin 53

Trim72 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Trim72	Q1XH17	Irs1	Mus musculus	P35569	Anti Bait CoIP	23354051
Intra	Trim72	Q1XH17	Irs1	Mus musculus	P35569	Anti Tag CoIP	23354051
Intra	Trim72	Q1XH17	Insr	Mus musculus	P15208	Anti Bait CoIP	23354051

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15071	TRIM72 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21211	Trim72 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27727	Trim72 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Trim72	NCBI	NCBI:493829