UNC13C - unc-13 homolog C Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 440279

About UNC13C

Cytogenetic location: 15q21.3 Genomic coordinates (GRCh38): 15:53,837,602-54,633,440 (from NCBI)

This gene has 6 transcripts (splice variants), 218 orthologues and 2 paralogues. Biased expression in brain (RPKM 3.2), thyroid (RPKM 0.4) and 4 other tissues.

Summary

Predicted to enable Calmodulin binding activity and syntaxin-1 binding activity. Predicted to be involved in several processes, including glutamatergic synaptic transmission; regulated exocytosis; and synaptic vesicle maturation. Predicted to be located in presynaptic active zone. Predicted to be active in several cellular components, including axon terminus; parallel fiber to Purkinje cell synapse; and presynaptic active zone cytoplasmic component. [provided by Alliance of Genome Resources, Apr 2022]

UNC13C Products (2)

mRNA Protein Name
NM_001080534.3 NP_001074003.1 protein unc-13 homolog C isoform 1
NM_001329919.2 NP_001316848.1 protein unc-13 homolog C isoform 2

UNC13C Protein Structure

C1_1

C1_1: Phorbol esters/diacylglycerol binding domain (C1 domain) (1098 - 1147)

C2

C2: C2 domain (1223 - 1312)

DUF1041

DUF1041: Domain of Unknown Function (DUF1041) (1540 - 1646)

Membr_traf_MHD

Membr_traf_MHD: Munc13 (mammalian uncoordinated) homology domain (1887 - 2028)

C2

C2: C2 domain (2064 - 2151)

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  • 2214 a.a.
Protein Preferred Names Protein Names

protein unc-13 homolog C

  • Munc13-3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15466 UNC13C Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus UNC13C VGNC VGNC:36665
Mus musculus UNC13C MGD MGI:2149021
Canis familiaris UNC13C VGNC VGNC:48135
Felis catus UNC13C VGNC VGNC:66823
Macaca mulatta UNC13C VGNC VGNC:99340
Rattus norvegicus UNC13C RGD RGD:628592
Others UNC13C NCBI