MSN - moesin Gene

Also Known as HEL70; IMD50

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4478

About MSN

Cytogenetic location: Xq12 Genomic coordinates (GRCh38): X:65,588,377-65,741,931 (from NCBI)

This gene has 16 transcripts (splice variants), 283 orthologues, 6 paralogues and is associated with 76 phenotypes. Ubiquitous expression in lung (RPKM 147.3), appendix (RPKM 142.6) and 24 other tissues.

Summary

Moesin (for membrane-organizing extension spike protein) is a member of the ERM family which includes ezrin and radixin. ERM proteins appear to function as cross-linkers between plasma membranes and actin-based cytoskeletons. Moesin is localized to filopodia and Other membranous protrusions that are important for cell-cell recognition and signaling and for cell movement. [provided by RefSeq, Jul 2008]

MSN Products (1)

mRNA	Protein	Name
NM_002444.3	NP_002435.1	moesin

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables cell adhesion molecule binding	IPI IPI: Inferred from physical interaction	12082081	GOA
enables double-stranded RNA binding	IDA IDA: Inferred from direct assay	21266579	GOA
enables enzyme binding	IPI IPI: Inferred from physical interaction	15922359	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	7844168	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	19255442	GOA
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	15819698	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in T cell aggregation	IDA IDA: Inferred from direct assay	27405666	GOA
involved in T cell migration	IDA IDA: Inferred from direct assay	27405666	GOA
involved in T cell proliferation	IDA IDA: Inferred from direct assay	27405666	GOA
involved in cellular response to testosterone stimulus	IDA IDA: Inferred from direct assay	24065547	GOA
involved in establishment of endothelial barrier	IGI IGI: Inferred from genetic interaction	23264465	GOA
involved in establishment of epithelial cell apical/basal polarity	IMP IMP: Inferred from mutant phenotype	24862762	GOA
involved in gland morphogenesis	IMP IMP: Inferred from mutant phenotype	24862762	GOA
involved in immunological synapse formation	IDA IDA: Inferred from direct assay	27405666	GOA
involved in leukocyte cell-cell adhesion	IEP IEP: Inferred from expression pattern	12082081	GOA
involved in leukocyte migration	IEP IEP: Inferred from expression pattern	12082081	GOA
involved in membrane to membrane docking	IEP IEP: Inferred from expression pattern	12082081	GOA
involved in positive regulation of early endosome to late endosome transport	IGI IGI: Inferred from genetic interaction	21148287	GOA
involved in positive regulation of gene expression	IGI IGI: Inferred from genetic interaction	23264465	GOA
involved in positive regulation of protein catabolic process	IGI IGI: Inferred from genetic interaction	21148287	GOA
involved in positive regulation of protein localization to early endosome	IGI IGI: Inferred from genetic interaction	21148287	GOA
involved in regulation of cell shape	IMP IMP: Inferred from mutant phenotype	24862762	GOA
NOT involved in regulation of cell size	IMP IMP: Inferred from mutant phenotype	22467863	GOA
involved in regulation of cell size	IMP IMP: Inferred from mutant phenotype	24862762	GOA
involved in regulation of lymphocyte migration	IMP IMP: Inferred from mutant phenotype	19255442	GOA
involved in regulation of organelle assembly	IGI IGI: Inferred from genetic interaction	21148287	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in apical part of cell	IDA IDA: Inferred from direct assay	12082081	GOA
located in apical plasma membrane	IDA IDA: Inferred from direct assay	24862762	GOA
located in cell periphery	IDA IDA: Inferred from direct assay	22291017	GOA
located in cell surface	IDA IDA: Inferred from direct assay	15922359	GOA
located in filopodium	IDA IDA: Inferred from direct assay	12082081	GOA
colocalizes with focal adhesion	IDA IDA: Inferred from direct assay	21282464	GOA
located in microvillus	IDA IDA: Inferred from direct assay	12082081	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	24862762	GOA
located in pseudopodium	IDA IDA: Inferred from direct assay	24065547	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MSN Protein Structure

FERM_N

FERM_M

FERM_C

ERM

0
100
200
300
400
500
577 a.a.

Protein Preferred Names	Protein Names
moesin	epididymis luminal protein 70

MSN Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	MSN	P26038	LMO2	Homo sapiens	P25791-3	Y2H Array	32296183
Intra	MSN	P26038	LMO2	Homo sapiens	P25791-3	Y2H Prey Pooling	32296183
Cross	MSN	P26038	Lrrk2	Mus musculus	Q5S006	Protein Kinase Assay	24794857
Intra	MSN	P26038	NHERF1	Homo sapiens	O14745	Pull Down	9430655
Intra	MSN	P26038	NHERF1	Homo sapiens	O14745	Affinity Chrom	15020681
Intra	MSN	P26038	NHERF1	Homo sapiens	O14745	X-Ray Diffraction	15020681
Intra	MSN	P26038	NHERF1	Homo sapiens	O14745	IF	9430655
Intra	MSN	P26038	CD44	Homo sapiens	P16070	Anti Bait CoIP	23855374
Intra	MSN	P26038	CD44	Homo sapiens	P16070	Confocal	23855374
Intra	MSN	P26038	LRRK2	Homo sapiens	Q5S007	Protein Kinase Assay	24351927
Intra	MSN	P26038	LRRK2	Homo sapiens	Q5S007	Protein Kinase Assay	24695735
Intra	MSN	P26038	LRRK2	Homo sapiens	Q5S007	Protein Kinase Assay	23241358
Intra	MSN	P26038	TERF1	Homo sapiens	P54274	BiFC	21044950
Intra	MSN	P26038	TERF1	Homo sapiens	P54274	Pull Down	21044950

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant MSN Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73806	Moesin Protein, Human (His)	P26038 (M1-E346)	≥ 80%, as determined by reducing SDS-PAGE.

MSN Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80228	Moesin Antibody (YA284)	WB, IHC-P, ICC/IF	Human, Mouse
HY-P82869	Phospho-Moesin (Thr558) Antibody (YA2614)	WB, IHC-P	Human, Rat
HY-P82869A	Phospho-Moesin (Thr558) Antibody (YA2614)(PBS only)	WB, IHC-P	Human, Rat

Related Diseases

Diseases	Alias
Immunodeficiency 50	Combined Immunodeficiency Due To Moesin Deficiency IMD50 Immunodeficiency 50, X-Linked Recessive Cid Due To Moesin Deficiency Msn-Related Combined Immunodeficiency X-Linked Moesin-Associated Immunodeficiency Immunodeficiency 50 X Linked Recessive
Verrucous Carcinoma	Verrucous Squamous Carcinoma Verrucous Squamous Cell Carcinoma Warty Carcinoma Carcinoma Verrucous Carcinoma, Verrucous
Acoustic Neuroma	Neurofibromatosis Type 2 Vestibular Schwannoma Acoustic Neurinoma Bilateral Acoustic Neurofibromatosis Nf2 Acoustic Neurilemoma Cerebellopontine Angle Tumor Neurofibromatosis Central Type Neurofibromatosis Type Ii Vestibular Neurilemmoma Acoustic Tumor Neurinoma Of The Acoustic Nerve Acoustic Neurinoma Bilateral Acoustic Schwannomas Bilateral Banf Central Neurofibromatosis Familial Acoustic Neuromas Neurofibromatosis 2 Neurofibromatosis Type 2 Merlin Schwannoma, Acoustic, Bilateral Neuroma Acoustic Neuroma, Acoustic Familial Acoustic Neuroma Familial Vestibular Schwannoma Neurofibromatosis, Central Type Nf2 - [Neurofibromatosis Type 2]
Measles	Rubeola Morbilli Measles Nos Koplik Spots
Neurilemmoma	Schwannoma Benign Schwannoma Neurilemoma Peripheral Fibroblastoma Psammomatous Schwannoma Neurolemmoma Schwannomas
Kindler Syndrome	Poikiloderma Of Kindler Bullous Acrokeratotic Poikiloderma Of Kindler And Weary Congenital Bullous Poikiloderma KNDLRS Poikiloderma, Hereditary Acrokeratotic Poikiloderma, Congenital, With Bullae, Weary Type Kindler'S Syndrome Poikiloderma Congenital With Bullae Weary Type Hereditary Acrokeratotic Poikiloderma Of Kindler-Weary Hereditary Acrokeratotic Poikiloderma Weary Syndrome Poikiloderma Hereditary Acrokeratotic Potassium Deficiency
Neurofibromatosis, Type Ii	Neurofibromatosis 2 Neurofibromatosis, Type 2 NF2 Neurofibromatosis Type Ii Bilateral Acoustic Neurofibromatosis Banf Acn Central Neurofibromatosis Neurofibromatosis, Central Type Acoustic Schwannomas, Bilateral Acoustic Neurinoma, Bilateral Bilateral Acoustic Neurinoma Bilateral Acoustic Schwannomas Familial Acoustic Neuromas
Anaplastic Large Cell Lymphoma	Alcl Cd30 Positive Anaplastic Large Cell Lymphoma Ki-1 Positive Anaplastic Large Cell Lymphoma Primary Systemic Alcl Sacl Ki-1+ Anaplastic Large Cell Lymphoma
Polyarteritis Nodosa	Polyarteritis Periarteritis Nodosa Pan Periarteritis Kussmaul-Maier Disease Panarteritis Nodosa Kussmaul Disease Pan - [Polyarteritis Nodosa] Polyangiitis Panangiitis Arteritis Nodosa
Wiskott-Aldrich Syndrome	WAS Eczema-Thrombocytopenia-Immunodeficiency Syndrome Immunodeficiency 2 Aldrich Syndrome Imd2 Wiskott-Aldrich Syndrome 1 Was1 Wiskott Syndrome Wiskott Aldrich Syndrome Eczema Thrombocytopenia Immunodeficiency Syndrome Imd 2
Meningioma, Familial	Meningioma Familial Meningioma Meningioma, Familial, Susceptibility To Meningeal Neoplasm Meningeal Neoplasms Meningiomas Meningioma, Nf2-Related, Somatic Meningioma, Sis-Related Meningothelial Cell Tumor Neoplasm Of The Meninges Primary Meningeal Tumor Familial Multiple Meningioma MNGMA Meningioma, Benign, No Icd-O Subtype Intracranial Meningioma Meningothelial Cell Neoplasm Supratentorial Meningioma Primary Neoplasm Of Spinal Meninges Benign Intracranial Meningioma Benign Meningioma Meningeal Tumours Meningeal Sarcoma Of Unspecified Site Meningothelial Sarcoma Of Unspecified Site
Neurofibromatosis	Neurofibromatoses Acoustic Neurofibromatosis Central Neurofibromatosis Peripheral Neurofibromatosis Recklinghausen'S Neurofibromatosis Von Reklinghausen Disease Neurofibromatosis Type 1
Deafness, Autosomal Recessive 24	DFNB24 Deafness, Autosomal Recessive, 24 Autosomal Recessive Nonsyndromic Deafness 24 Autosomal Recessive Deafness 24 Deafness, Autosomal Recessive, Type 24
Leukocyte Adhesion Deficiency, Type Iii	Leukocyte Adhesion Deficiency 3 LAD3 Leukocyte Adhesion Deficiency 1 Variant Lad1v Integrin Activation Deficiency Disease Iadd Leukocyte Adhesion Deficiency Type Iii Lad1 Variant Lad-1 Variant Lad-Iii Leukocyte Adhesion Deficiency-1 Variant Leukocyte Adhesion Deficiency Type 1
Optic Nerve Sheath Meningioma	Meningioma Of Optic Nerve Sheath
Petrous Apex Meningioma	Meningioma Of The Petrous Ridge
Neurilemmomatosis	Schwannomatosis Neurofibromatosis Type 3 Nf3 Neurilemmomatosis Congenital Cutaneous Neurinomatosis Congenital Cutaneous Neurilemmomatosis Multiple Neurilemmomas Multiple Schwannomas Neurilemmomatosis, Congenital Cutaneous Schwannomatosis 1 Neurofibromatosis 3 Mixed Central And Peripheral Neurofibromatosis Nf3 - [Neurofibromatosis Type 3]
Joubert Syndrome 1	Joubert Syndrome Jbts Cerebellooculorenal Syndrome 1 JBTS1 Joubert-Boltshauser Syndrome Cerebelloparenchymal Disorder Iv Cpd4 Cors1 Joubert Syndrome And Related Disorders Jsrd Familial Aplasia Of The Vermis Joubert Syndrome Related Disorders Js Cerebellar Vermis Agenesis Cerebelloparenchymal Disorder 4 Agenesis Of Cerebellar Vermis Cerebello-Oculo-Renal Syndrome Cors Joubert-Bolthauser Syndrome Cpd Iv Classic Joubert Syndrome Joubert Syndrome Type A Pure Joubert Syndrome Cerebello-Oculo-Renal Syndrome 1 Joubert Syndrome-1 Joubert Syndrome, Type 1 Joubert'S Syndrome
Parkinson Disease, Late-Onset	Parkinson Disease Parkinson'S Disease PD PARK Parkinson Disease, Susceptibility To Late Onset Parkinson'S Disease Late Onset Parkinson Disease Paralysis Agitans Primary Parkinsonism Idiopathic Parkinson Disease Parkinson'S Parkinson Disease, Late-Onset, Susceptibility To Parkinson Disease, Age Of Onset, Modifier Lewy Body Parkinson Disease Idiopathic Parkinson'S Disease Pd - [Parkinson Disease] Parkinson Disease Nos Parkinson, Nos Primary Parkinson Disease
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Pre-clinical Phase

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P1386	D15	Inhibitor	99.02%	Unkown

Pre-clinical Phase

Bioactive Molecules (12)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12646	Rhosin hydrochloride		99.94%	Unkown
HY-12646A	Rhosin		98.74%	Unkown
HY-120079	MSN-125	Inhibitor	99.67%	Unkown
HY-118948	MSN-50	Inhibitor	98.09%	Unkown
HY-42984	BHQ-2 NHS	Inhibitor	97.70%	Unkown
HY-140678	mPEG10000-amine		98.0%	Unkown
HY-RS18452	Msn Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-149410	MSN8C	Inhibitor	/	Unkown
HY-174929	DBCO-PEG3400-Amine		/	Unkown
HY-174929A	DBCO-PEG5000-Amine		/	Unkown
HY-RS08723	MSN Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24933	Msn Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	MSN	VGNC	VGNC:68328
Mus musculus	MSN	MGD	MGI:97167
Rattus norvegicus	MSN	RGD	RGD:621260
Macaca mulatta	MSN	VGNC	VGNC:74938
Canis familiaris	MSN	VGNC	VGNC:43447
Bos taurus	MSN	VGNC	VGNC:31703
Others	MSN	NCBI