1. Apoptosis
  2. Bcl-2 Family
  3. MSN-125

MSN-125 

Cat. No.: HY-120079
Handling Instructions

MSN-125 is a potent Bax and Bak oligomerization inhibitor. MSN-125 prevents mitochondrial outer membrane permeabilization (MOMP) with an IC50 of 4 μM. MSN-125 potently inhibits Bax/Bak-mediated apoptosis in HCT-116, BMK Cells, and primary cortical neurons, protects primary neurons against glutamate excitotoxicity.

For research use only. We do not sell to patients.

MSN-125 Chemical Structure

MSN-125 Chemical Structure

CAS No. : 1592908-16-1

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Description

MSN-125 is a potent Bax and Bak oligomerization inhibitor. MSN-125 prevents mitochondrial outer membrane permeabilization (MOMP) with an IC50 of 4 μM. MSN-125 potently inhibits Bax/Bak-mediated apoptosis in HCT-116, BMK Cells, and primary cortical neurons, protects primary neurons against glutamate excitotoxicity[1].

IC50 & Target[1]

Bax

 

Bak

 

In Vitro

MSN-125 inhibits tBid/Bax-mediated MOMP in a concentration-dependent manner[1].

Molecular Weight

688.61

Formula

C₃₆H₃₈BrN₃O₆

CAS No.

1592908-16-1

SMILES

O=C(C1=CC=CC=C1)N[[email protected]@H](CC2=CC=CC=C2)C(N(CC3=CC=C(C=C3)Br)[[email protected]@H]4[[email protected]](OC5=CC(OCOCCOC)=CC=C45)CN)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

MSN-125MSN125MSN 125Bcl-2 FamilymitochondrialoutermembranepermeabilizationMOMPoligomerizationapoptosisliposomeInhibitorinhibitorinhibit

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MSN-125
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HY-120079
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