Phospho-Moesin (Thr558) Antibody (YA2614)

Art. -Nr.: HY-P82869: Data Sheet COA
SDS
User Guide for Antibodies
FAQs
Technical Support

Phospho-Moesin (Thr558) Antibody (YA2614) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-Moesin (Thr558).

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10 μL	Auf Lager	Estimated Time of Arrival: December 31
50 μL	Auf Lager	Estimated Time of Arrival: December 31
100 μL	Auf Lager	Estimated Time of Arrival: December 31
250 μL	Angebot einholen

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Phospho-Moesin (Thr558) Antibody (YA2614) Spezialitätsempfehlungen:

WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Beschreibung

Beschreibung

Phospho-Moesin (Thr558) Antibody (YA2614) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-Moesin (Thr558).

Host

Rabbit

Clonality

Recombinant, Monoclonal

Molekulargewicht

Predicted band size: 68 kDa;

Observed band size: 68 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human, Rat

SwissProt ID

P26038

Gene ID

4478 [NCBI]

Immunogen

A synthetic phosphopeptide corresponding to residues surrounding Thr558 of human Moesin

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:500-1:1000
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:50-1:100

Sensitivity	Endogenous	Reinheit	Affinity Purified
Conjugation	Non-conjugated	Modification	Phosphorylated
Isotype	IgG

Appearance

Liquid

Formulation

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Versand

Shipping with blue ice.

Background

Function：Ezrin-radixin-moesin (ERM) family protein that connects the actin cytoskeleton to the plasma membrane and thereby regulates the structure and function of specific domains of the cell cortex. Tethers actin filaments by oscillating between a resting and an activated state providing transient interactions between moesin and the actin cytoskeleton (PubMed:10212266). Once phosphorylated on its C-terminal threonine, moesin is activated leading to interaction with F-actin and cytoskeletal rearrangement (PubMed:10212266). These rearrangements regulate many cellular processes, including cell shape determination, membrane transport, and signal transduction (PubMed:12387735, PubMed:15039356). The role of moesin is particularly important in immunity acting on both T and B-cells homeostasis and self-tolerance, regulating lymphocyte egress from lymphoid organs (PubMed:9298994, PubMed:9616160). Modulates phagolysosomal biogenesis in macrophages (By similarity). Also participates in immunologic synapse formation (PubMed:27405666)

Subcellular Localization：Cell membrane; Peripheral membrane protein; Cytoplasmic side; Cytoplasm, cytoskeleton; Apical cell membrane; Peripheral membrane protein; Cytoplasmic side; Cell projection, microvillus membrane; Peripheral membrane protein; Cytoplasmic side; Cell projection, microvillus

Expression：
Tissue_specificity:In all the tissues and cultured cells studied

Subunit：In resting T-cells, part of a PAG1-NHERF1-MSN complex which is disrupted upon TCR activation. Interacts with NHERF1 (PubMed:15020681, PubMed:9314537). Interacts with PPP1R16B (PubMed:18586956). Interacts with SELPLG and SYK; these interactions mediate the activation of SYK by SELPLG (PubMed:12387735). Interacts with PDPN (via cytoplasmic domain); this interaction activates RHOA and promotes epithelial-mesenchymal transition (PubMed:17046996). Interacts with SPN/CD43 cytoplasmic tail (PubMed:11728332, PubMed:9616160). Interacts with CD44 (PubMed:9298994). Interacts with ICAM2 (By similarity). Interacts with ICAM3 (via C-terminus) (PubMed:9298994). Interacts with PDZD8 (PubMed:21549406). Interacts with F-actin (PubMed:10212266). Interacts with CD46 (PubMed:7884872). Interacts with PTPN6 (By similarity)

RRID

AB_3104962

Database

Entrez Gene: 4478 Human ; 17698 Mouse ; 81521 Rat

SwissProt: P26038 Human ; P26041 Mouse ; O35763 Rat

OMIM: 300988 Human

Research Field

Signal Transduction

Synonyms

MSN; Moesin; Membrane-organizing extension spike protein; RDX; Radixin; EZR; VIL2; Ezrin; Cytovillin; Villin-2; p81

Dokumentation

Select Batch:

Data Sheet (235 KB) SDS (251 KB)

COA (206 KB)

User Guide for Antibodies (1077 KB)

Phospho-Moesin (Thr558) Antibody (YA2614) Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Phospho-Moesin (Thr558) Antibody (YA2614)

Phospho-Moesin (Thr558) Antibody (YA2614) Spezialitätsempfehlungen:

Product Detail

Background

Beschreibung

Phospho-Moesin (Thr558) Antibody (YA2614) Related Classifications

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