PRMT5 - protein arginine methyltransferase 5 Gene

Species: Canis lupus familiaris (sub-species: familiaris)

Gene Type: protein coding
Gene ID: 480242

About PRMT5

Primary_assembly 8: 3,356,165-3,365,310 reverse strand.ROS_Cfam_1.0:CM025107.1

This gene has 5 transcripts (splice variants) and 200 orthologues.

PRMT5 Products (5)

mRNA Protein Name
XM_038673103.1 XP_038529031.1 protein arginine N-methyltransferase 5 isoform X4
XM_038673100.1 XP_038529028.1 protein arginine N-methyltransferase 5 isoform X1
XM_038673102.1 XP_038529030.1 protein arginine N-methyltransferase 5 isoform X3
XM_038673104.1 XP_038529032.1 protein arginine N-methyltransferase 5 isoform X5
XM_038673101.1 XP_038529029.1 protein arginine N-methyltransferase 5 isoform X2

PRMT5 Protein Structure

PRMT5_TIM

PRMT5_TIM: pfam17285 (36 - 299)

PRMT5

PRMT5: pfam05185 (304 - 473)

PRMT5_C

PRMT5_C: pfam17286 (477 - 644)

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  • 600
  • 647 a.a.
Protein Preferred Names Protein Names

protein arginine N-methyltransferase 5

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-101563 GSK3326595 Inhibitor 99.83% Phase 2
HY-101564 Onametostat Inhibitor 99.79% Phase 1
HY-131493 PF-06939999 Inhibitor 99.84% Phase 1

Pre-clinical Phase

Bioactive Molecules (55)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-139611 Navlimetostat Inhibitor 99.28% Unkown
HY-12727 EPZ015666 Inhibitor 99.86% Unkown
HY-100235 GSK591 Inhibitor 99.91% Unkown
HY-107777 LLY-283 Inhibitor 98.93% Unkown
HY-148419 Ralometostat Inhibitor 99.90% Unkown
HY-141877 MS4322 Degrader 99.14% Unkown
HY-124131 DS-437 Inhibitor 99.22% Unkown
HY-100025A HLCL-61 hydrochloride Inhibitor 99.87% Unkown
HY-132309 BRD0639 Inhibitor 98.04% Unkown
HY-138684 MRTX9768 Inhibitor 99.60% Unkown
HY-139611C Navlimetostat hydrochloride Inhibitor 99.61% Unkown
HY-148674 AM-9747 Inhibitor 99.76% Unkown
HY-109963 PR5-LL-CM01 Inhibitor 98.37% Unkown
HY-Q36691 PRMT5-IN-30 Inhibitor 99.35% Unkown
HY-139611B (S)-Navlimetostat Inhibitor 98.15% Unkown
HY-141877B MS4322 (isomer) 99.87% Unkown
HY-120137 CMP-5 Inhibitor 99.61% Unkown
HY-158143 AZD3470 Inhibitor 99.74% Unkown
HY-128579 DW14800 Inhibitor 99.12% Unkown
HY-126256A PRMT5-IN-1 hydrochloride Inhibitor 99.51% Unkown
HY-111213 PRMT5-IN-20 Inhibitor 99.20% Unkown
HY-W072962 WX2-43 Inhibitor 98.74% Unkown
HY-126256 PRMT5-IN-1 Inhibitor / Unkown
HY-138684A MRTX9768 hydrochloride Inhibitor 99.88% Unkown
HY-182820 YZ-836P / Unkown
HY-134883 PRMT5-IN-4 Inhibitor 99.0% Unkown
HY-141876 PRT543 Inhibitor / Unkown
HY-182892 MC4491 Inhibitor / Unkown
HY-175821 PRMT1-IN-3 Inhibitor / Unkown
HY-168842 PRMT5-IN-47 Inhibitor / Unkown
HY-P3822 PRMT5-IN-23 Inhibitor / Unkown
HY-180356 PRMT5-IN-54 Inhibitor / Unkown
HY-132937 PRMT5-IN-9 Inhibitor / Unkown
HY-146810 PRMT4-IN-1 Inhibitor / Unkown
HY-153421 PRMT5-IN-28 Inhibitor / Unkown
HY-176702 PRMT5-MTA-IN-5 Inhibitor / Unkown
HY-176701 PRMT5-MTA-IN-4 Inhibitor / Unkown
HY-163592 PRMT5-IN-43 Inhibitor / Unkown
HY-181522 PRMT5 ligand 3 Ligand / Unkown
HY-183951 TNG456 Inhibitor / Unkown
HY-168263 PRMT5-IN-45 Inhibitor / Unkown
HY-149005 PRMT5-IN-19 Inhibitor / Unkown
HY-163591 PRMT5-IN-36-d3 Inhibitor / Unkown
HY-162230 PRMT5-IN-33 Inhibitor / Unkown
HY-163587 PRMT5-IN-39-d3 Inhibitor / Unkown
HY-169708 PRMT5-IN-49 Inhibitor / Unkown
HY-163799 PRMT5-MTA-IN-1 Inhibitor / Unkown
HY-161334 CARM1-IN-4 Inhibitor / Unkown
HY-163593 PRMT5-IN-44 Inhibitor / Unkown
HY-176534 PRMT5-IN-52 Inhibitor / Unkown
HY-111213A PRMT5-IN-20 hydrochloride Ligand / Unkown
HY-173092 PRMT5 ligand 1 Ligand / Unkown
HY-178028 PRMT5-IN-53 Inhibitor / Unkown
HY-181521 RAPRMT5 Degrader / Unkown
HY-150081 PRMT5-IN-21 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens PRMT5 NCBI NCBI:10419