2. Gene
  3. RAF1 - Raf-1 proto-oncogene, serine/threonine kinase Gene

RAF1 - Raf-1 proto-oncogene, serine/threonine kinase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Canis lupus familiaris (sub-species: familiaris)
Gene ID: 484648 | Gene type: protein coding

About RAF1

Primary_assembly 20: 5,921,827-6,000,864 forward strand.ROS_Cfam_1.0:CM025119.1

This gene has 2 transcripts (splice variants), 219 orthologues and 22 paralogues.

RAF1 Products(5)

mRNA Protein Name
XM_038426895.1 XP_038282823.1 RAF proto-oncogene serine/threonine-protein kinase isoform X4
XM_038426893.1 XP_038282821.1 RAF proto-oncogene serine/threonine-protein kinase isoform X2
XM_038426892.1 XP_038282820.1 RAF proto-oncogene serine/threonine-protein kinase isoform X1
XM_038426894.1 XP_038282822.1 RAF proto-oncogene serine/threonine-protein kinase isoform X3
XM_038426891.1 XP_038282819.1 RAF proto-oncogene serine/threonine-protein kinase isoform X1

RAF1 Protein Structure

RBD_CRAF

RBD_CRAF: cd17135 (54 - 130)

C1_A_C-Raf

C1_A_C-Raf: cd20870 (135 - 186)

STKc_C-Raf

STKc_C-Raf: cd14149 (355 - 637)

  • 0
  • 200
  • 400
  • 600
  • 668 a.a.
Protein Preferred Names Protein Names

RAF proto-oncogene serine/threonine-protein kinase

v-raf-1 murine leukemia viral oncogene homolog 1

Related Agents

Approval
Bioactive Molecules (9)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-12057 Vemurafenib 99.90% Yes
HY-10331 Regorafenib 99.93% Yes
HY-10201S Sorafenib-d3 99.57% Unkown
HY-10331A Regorafenib monohydrate 99.94% Yes
HY-N6670 Cefotetan 99.75% Unkown
HY-13308 Regorafenib Hydrochloride 99.58% Yes
HY-10201R Sorafenib (Standard) 99.71% Unkown
HY-10331B Regorafenib mesylate / Unkown
HY-10201AR Sorafenib tosylate (Standard) / Unkown
Clinical Phase
Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Phase
HY-159127 HRS-4642 98.38% Phase 2
HY-114491 Rineterkib Inhibitor 98.79% Phase 2
HY-114491A Rineterkib hydrochloride Inhibitor 99.81% Phase 2
HY-134813 MRTX1133 Inhibitor 99.97% Phase 1
HY-51424 PLX-4720 Inhibitor 99.90% Phase 1
HY-158107 BBO-8520 Inhibitor 99.90% Phase 1
Pre-clinical Phase
Bioactive Molecules (42)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-11004 AZ 628 99.44% Unkown
HY-18832 AWL-II-38.3 Inhibitor 99.71% Unkown
HY-I0678 Regorafénib N-oxyde (M2) 99.32% Unkown
HY-W013411A Locostatin 99.88% Unkown
HY-P1039A R18 TFA 99.65% Unkown
HY-122914 KRAS inhibitor-3 Inhibitor 99.87% Unkown
HY-123673 MCP110 Inhibitor 99.82% Unkown
HY-15716 Kobe0065 99.93% Unkown
HY-115501 (E)-FOBISIN101 95.63% Unkown
HY-117737A RRD-251 99.87% Unkown
HY-15717 Kobe2602 Inhibitor 98.20% Unkown
HY-181420A BBO-11818 / Unkown
HY-10201S2 Sorafenib-13C,d3 98.35% Unkown
HY-177511 KRAS G12D-IN-30 Inhibitor 99.38% Unkown
HY-134813A MRTX1133 formic Inhibitor 98.23% Unkown
HY-158107A (4R)-BBO-8520 Inhibitor / Unkown
HY-164365 PROTAC K-Ras Degrader-2 Degrader / Unkown
HY-P1039 R18 / Unkown
HY-W013411 (E/Z)-Locostatin Control 99.52% Unkown
HY-10201S1 Sorafenib-d4 99.9% Unkown
HY-10201S4 Sorafenib-d3 tosylate Inhibitor / Unkown
HY-10331S1 Regorafenib-13C,d3 / Unkown
HY-12057S Vemurafenib-d5 / Unkown
HY-12057S1 Vemurafenib-d7 / Unkown
HY-161760 Ferroptosis inducer-3 Inhibitor / Unkown
HY-175870A (7R)-Eras-4001 Inhibitor / Unkown
HY-179133 HDB-1 Inhibitor 98.02% Unkown
HY-182749 KRAS-IN-58 Inhibitor / Unkown
HY-183674 MEK-IN-10 / Unkown
HY-E70747 MEK5 Recombinant Human Active Protein Kinase / Unkown
HY-E70765 RAF1 YDYD Recombinant Human Active Protein Kinase / Unkown
HY-I0678S Regorafénib N-oxyde-d3 (M2) / Unkown
HY-I0678S1 Regorafénib N-oxyde (M2)-13C,d3 / Unkown
HY-N13009 MO-2097 / Unkown
HY-RS11619 RAF1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11620 Raf1 Mouse Pre-designed siRNA Set A / Unkown
HY-RS11621 Raf1 Rat Pre-designed siRNA Set A / Unkown
HY-RS12020 RNASE3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W1126467 RAS-IN-5 Inhibitor / Unkown
HY-51424S PLX-4720-d7 Inhibitor / Unkown
HY-N15264 Azaspirene Inhibitor / Unkown
HY-RS26697 Rnase2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens RAF1 NCBI NCBI:5894