Xdh - xanthine dehydrogenase Gene

Also Known as XOR

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 497811

About Xdh

Primary_assembly 6: 21,530,113-21,592,268 forward strand.mRatBN7.2:CM026979.1

This gene has 3 transcripts (splice variants), 208 orthologues, 3 paralogues and is associated with 76 phenotypes. Biased expression in Adrenal (RPKM 637.6), Spleen (RPKM 495.4) and 8 other tissues.

Summary

This gene encodes a member of the xanthine dehydrogenase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. The encoded protein is involved in purine degradation and functions as both a dehydrogenase and an oxidase. [provided by RefSeq, Jan 2014]

Xdh Products (1)

mRNA	Protein	Name
NM_017154.2	NP_058850.2	xanthine dehydrogenase/oxidase

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables 2 iron, 2 sulfur cluster binding	IDA IDA: Inferred from direct assay	2549869	RGD
enables flavin adenine dinucleotide binding	IDA IDA: Inferred from direct assay	15878860	RGD
enables identical protein binding	IPI IPI: Inferred from physical interaction	2549869	RGD
enables molybdopterin cofactor binding	IDA IDA: Inferred from direct assay	15878860	RGD
enables nitrite reductase (NO-forming) activity	IDA IDA: Inferred from direct assay	25537183	RGD
enables xanthine dehydrogenase activity	IDA IDA: Inferred from direct assay	2387845	RGD
enables xanthine oxidase activity	IDA IDA: Inferred from direct assay	2387845	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in adenosine catabolic process	IDA IDA: Inferred from direct assay	1619276	RGD
involved in allantoin metabolic process	IDA IDA: Inferred from direct assay	1619276	RGD
involved in cellular response to interleukin-1	IEP IEP: Inferred from expression pattern	12653206	RGD
involved in cellular response to tumor necrosis factor	IEP IEP: Inferred from expression pattern	12653206	RGD
involved in guanine catabolic process	IDA IDA: Inferred from direct assay	3443108	RGD
involved in hypoxanthine catabolic process	IDA IDA: Inferred from direct assay	232638	RGD
involved in inosine catabolic process	IDA IDA: Inferred from direct assay	1619276	RGD
involved in response to aluminum ion	IDA IDA: Inferred from direct assay	11787993	RGD
involved in response to azide	IEP IEP: Inferred from expression pattern	23174561	RGD
involved in response to carbon monoxide	IEP IEP: Inferred from expression pattern	8248931	RGD
involved in response to hydrogen peroxide	IEP IEP: Inferred from expression pattern	3162724	RGD
involved in response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	24378112	RGD
involved in xanthine catabolic process	IDA IDA: Inferred from direct assay	3443108	RGD

Cellular Component GO Annotation	Evidence	References	Source
is active in cytosol	IDA IDA: Inferred from direct assay	1619276	RGD
located in extracellular space	IDA IDA: Inferred from direct assay	14728722	RGD
is active in peroxisome	IDA IDA: Inferred from direct assay	3443108	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Xdh Protein Structure

PLN02906

0
300
600
900
1200
1331 a.a.

Protein Preferred Names	Protein Names
xanthine dehydrogenase/oxidase	xanthine oxidase xanthine oxidoreductase

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-W012658	2-Methylacetophenone	Inhibitor	99.60%	Unkown
HY-RS15869	XDH Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS15870	Xdh Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-106300	AA 193	Inhibitor	/	Unkown
HY-RS13573	SORD Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS15871	Xdh Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W012658R	2-Methylacetophenone (Standard)	Inhibitor	/	Unkown
HY-RS18973	Sord Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25462	Sord Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Xdh	NCBI	NCBI:7498