Cps1 - carbamoyl-phosphate synthase 1 Gene

Also Known as cps; cps-1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 497840

Summary

Enables several functions, including anion binding activity; calcium ion binding activity; and carbamoyl-phosphate synthase (ammonia) activity. Involved in several processes, including cellular response to cAMP; cellular response to oleic acid; and response to peptide hormone. Located in mitochondrial inner membrane. Part of protein-containing complex. Biomarker of fatty liver disease; hypertension; and obesity. Human ortholog(s) of this gene implicated in carbamoyl phosphate synthetase I deficiency disease; persistent fetal circulation syndrome; and vascular disease. Orthologous to human CPS1 (carbamoyl-phosphate synthase 1). [provided by Alliance of Genome Resources, Apr 2022]

Cps1 Products (1)

mRNA Protein Name
NM_017072.2 NP_058768.1 carbamoyl-phosphate synthase [ammonia], mitochondrial precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ATP binding IDA
IDA: Inferred from direct assay
11577071 RGD
enables calcium ion binding IPI
IPI: Inferred from physical interaction
9506839 RGD
enables carbamoyl-phosphate synthase (ammonia) activity IDA
IDA: Inferred from direct assay
3680220 RGD
enables endopeptidase activity IDA
IDA: Inferred from direct assay
15304357 RGD
enables glutamate binding IPI
IPI: Inferred from physical interaction
8663466 RGD
enables phospholipid binding IDA
IDA: Inferred from direct assay
3680220 RGD
enables phospholipid binding IPI
IPI: Inferred from physical interaction
1898084 RGD
enables protein-containing complex binding IDA
IDA: Inferred from direct assay
17669278 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to cAMP IEP
IEP: Inferred from expression pattern
17397987 RGD
involved in cellular response to fibroblast growth factor stimulus IEP
IEP: Inferred from expression pattern
12832696 RGD
involved in cellular response to glucagon stimulus IEP
IEP: Inferred from expression pattern
8460937 RGD
involved in cellular response to oleic acid IEP
IEP: Inferred from expression pattern
8985169 RGD
involved in hepatocyte differentiation IEP
IEP: Inferred from expression pattern
12939595 RGD
involved in liver development IEP
IEP: Inferred from expression pattern
8690412 RGD
involved in midgut development IEP
IEP: Inferred from expression pattern
9544996 RGD
involved in monoatomic anion homeostasis IDA
IDA: Inferred from direct assay
4062872 RGD
involved in response to amine IEP
IEP: Inferred from expression pattern
2864015 RGD
involved in response to amino acid IEP
IEP: Inferred from expression pattern
11738098 RGD
involved in response to cAMP IEP
IEP: Inferred from expression pattern
6092398 RGD
involved in response to dexamethasone IEP
IEP: Inferred from expression pattern
19446026 RGD
involved in response to food IEP
IEP: Inferred from expression pattern
15481768 RGD
involved in response to glucagon IEP
IEP: Inferred from expression pattern
3754512 RGD
involved in response to glucocorticoid IEP
IEP: Inferred from expression pattern
8985169 RGD
involved in response to growth hormone IEP
IEP: Inferred from expression pattern
9688877 RGD
involved in response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
17539997 RGD
involved in response to oleic acid IEP
IEP: Inferred from expression pattern
8985169 RGD
involved in response to starvation IEP
IEP: Inferred from expression pattern
1979948 RGD
involved in response to steroid hormone IEP
IEP: Inferred from expression pattern
9688877 RGD
involved in response to toxic substance IEP
IEP: Inferred from expression pattern
14625847 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
19135993 RGD
involved in response to zinc ion IEP
IEP: Inferred from expression pattern
12840196 RGD
involved in urea cycle IDA
IDA: Inferred from direct assay
3680220 RGD
Cellular Component GO Annotation Evidence References Source
located in mitochondrial inner membrane IDA
IDA: Inferred from direct assay
3680220 RGD
located in mitochondrion IDA
IDA: Inferred from direct assay
14561759 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
17669278 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

carbamoyl-phosphate synthase [ammonia], mitochondrial

  • CPSase I

  • carbamoyl-phosphate synthetase 1, mitochondrial

  • carbamoyl-phosphate synthetase I

  • carbamyl phosphate synthetase I

  • carbamyl-phosphate synthetase

  • carboamyl-phosphate synthetase 1

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0711 Carglumic Acid Activator 99.90% Yes
HY-B0711R Carglumic Acid (Standard) Activator 99.91% Unkown

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-136128 H3B-120 Inhibitor 98.36% Unkown
HY-183888 H3B-616 Inhibitor / Unkown
HY-RS03115 CPS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03445 CYP21A2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10757 PM20D1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17488 Cps1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23946 Cps1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cps1 NCBI NCBI:1373