Cps1 - carbamoyl-phosphate synthase 1 Gene

Rattus norvegicus

Also known as cps; cps-1

Gene ID: 497840 | Gene type: protein coding

About Cps1

Summary

Enables several functions, including anion binding activity; calcium ion binding activity; and carbamoyl-phosphate synthase (ammonia) activity. Involved in several processes, including cellular response to cAMP; cellular response to oleic acid; and response to peptide hormone. Located in mitochondrial inner membrane. Part of protein-containing complex. Biomarker of fatty liver disease; hypertension; and obesity. Human ortholog(s) of this gene implicated in carbamoyl phosphate synthetase I deficiency disease; persistent fetal circulation syndrome; and vascular disease. Orthologous to human CPS1 (carbamoyl-phosphate synthase 1). [provided by Alliance of Genome Resources, Apr 2022]

Cps1 Products(1)

mRNA	Protein	Name
NM_017072.2	NP_058768.1	carbamoyl-phosphate synthase [ammonia], mitochondrial precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATP binding	IDA IDA: Inferred from direct assay	11577071	RGD
enables calcium ion binding	IPI IPI: Inferred from physical interaction	9506839	RGD
enables carbamoyl-phosphate synthase (ammonia) activity	IDA IDA: Inferred from direct assay	3680220	RGD
enables endopeptidase activity	IDA IDA: Inferred from direct assay	15304357	RGD
enables glutamate binding	IPI IPI: Inferred from physical interaction	8663466	RGD
enables phospholipid binding	IDA IDA: Inferred from direct assay	3680220	RGD
enables phospholipid binding	IPI IPI: Inferred from physical interaction	1898084	RGD
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	17669278	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to cAMP	IEP IEP: Inferred from expression pattern	17397987	RGD
involved in cellular response to fibroblast growth factor stimulus	IEP IEP: Inferred from expression pattern	12832696	RGD
involved in cellular response to glucagon stimulus	IEP IEP: Inferred from expression pattern	8460937	RGD
involved in cellular response to oleic acid	IEP IEP: Inferred from expression pattern	8985169	RGD
involved in hepatocyte differentiation	IEP IEP: Inferred from expression pattern	12939595	RGD
involved in liver development	IEP IEP: Inferred from expression pattern	8690412	RGD
involved in midgut development	IEP IEP: Inferred from expression pattern	9544996	RGD
involved in monoatomic anion homeostasis	IDA IDA: Inferred from direct assay	4062872	RGD
involved in response to amine	IEP IEP: Inferred from expression pattern	2864015	RGD
involved in response to amino acid	IEP IEP: Inferred from expression pattern	11738098	RGD
involved in response to cAMP	IEP IEP: Inferred from expression pattern	6092398	RGD
involved in response to dexamethasone	IEP IEP: Inferred from expression pattern	19446026	RGD
involved in response to food	IEP IEP: Inferred from expression pattern	15481768	RGD
involved in response to glucagon	IEP IEP: Inferred from expression pattern	3754512	RGD
involved in response to glucocorticoid	IEP IEP: Inferred from expression pattern	8985169	RGD
involved in response to growth hormone	IEP IEP: Inferred from expression pattern	9688877	RGD
involved in response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	17539997	RGD
involved in response to oleic acid	IEP IEP: Inferred from expression pattern	8985169	RGD
involved in response to starvation	IEP IEP: Inferred from expression pattern	1979948	RGD
involved in response to steroid hormone	IEP IEP: Inferred from expression pattern	9688877	RGD
involved in response to toxic substance	IEP IEP: Inferred from expression pattern	14625847	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	19135993	RGD
involved in response to zinc ion	IEP IEP: Inferred from expression pattern	12840196	RGD
involved in urea cycle	IDA IDA: Inferred from direct assay	3680220	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in mitochondrial inner membrane	IDA IDA: Inferred from direct assay	3680220	RGD
located in mitochondrion	IDA IDA: Inferred from direct assay	14561759	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	17669278	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

carbamoyl-phosphate synthase [ammonia], mitochondrial

CPSase I	carbamoyl-phosphate synthetase 1, mitochondrial
carbamoyl-phosphate synthetase I	carbamyl phosphate synthetase I
carbamyl-phosphate synthetase	carboamyl-phosphate synthetase 1

Related Agents

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0711	Carglumic Acid	Activator	99.84%	Yes
HY-B0711R	Carglumic Acid (Standard)	Activator	/	Unkown

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-136128	H3B-120	Inhibitor	98.20%	Unkown
HY-137199	Pro-Phe-Arg-AMC		/	Unkown
HY-RS03115	CPS1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cps1	NCBI	NCBI:1373

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